研究業績

■基本データ（2023年9月現在）

Original Articles: 183

Reviews: 22

Proceedings & book chapters: 22

Invited international symposia: 38

国内招待講演: 58

総説: 31

書籍（単著）: 1

書籍（編集）: 4

書籍（分担）: 25

  

Google Scholar 

h-index: 75

Number of total citations: 17,247

i-10 index: 184

*************************************************************************

 

*Corresponding author

 

Original Articles

183) Role of extracellular vesicles in absorption and functional mechanisms of quercetin, Akari Ishisaka, Ryosuke Sugimoto, Haruka Marumo, Tomoki Doi, Kaede Hamada, Misa Fujimoto, Nao Fujiwara, Masao Yamasaki, Akira Murakami*, Mol Nutr Food Res, in press (2023)

 

182) Transfer of quercetin ingested by maternal mice to neonatal mice via breast milk, Nao Fujiwara, Rie Mukai, Miyu Nishikawa, Shinichi Ikushiro, Akira Murakami, Akari Ishisaka*, Biosci Biotechnol Biochem, 87(4):442-447 (2022).

 

181) Auraptene, a citrus peel-derived natural product, prevents myocardial infarction-induced heart failure by activating PPARa in rats, Yoichi Sunagawa, Shogo Kawauchi, Yusuke Miyazaki, Yasufumi Katanasaka, Masafumi Funamoto, Kana Shimizu, Satoshi Shimizu, Hidetoshi Hamabe-Horiike, Maki Komiyama, Kiyoshi Mori, Akira Murakami, Koji Hasegawa, Tatsuya Morimoto*, Phytomedicine,107:154457 (2022)

 

180) Zerumbone prevents pressure overload-induced left ventricular systolic dysfunction by inhibiting cardiac hypertrophy and fibrosis, Nurmila Sari, Yasufumi Katanasaka, Yuga Sugiyama, Yoichi Sunagawa, Yusuke Miyazaki, Masafumi Funamoto, Satoshi Shimizu, Kana Shimizu, Akira Murakami, Kiyoshi Mori, Horomichi Wada, Koji Hasegawa, Tatsuya Morimoto*, Phytomedicine, 92, 153744 (2021)

 

179) Luteolin suppresses 5-hydroxytryptamine elevation in stimulation RBL-2H3 cells and experimental colitis mice, Naoko Suga, Akira Murakami, Hideyuki Arimitsu, Toshiyuki Nakamura, Yoshimasa Nakamura, Yoji Kato*, J Clin Biochem Nutr, 69(1) 20-27 (2021).

 

178) Elevation of the serotonin-derived quinone, tryptamine-4,5-dione, in the intestine of ICR mice with dextran sulfate-induced colitis. Naoko Suga, Akira Murakamni, Hideyuki Arimitsu, Kazuya Shiogama, Sarasa Tanaka, Mikiko Ito, Yoji Kato*, J Clin Biochem Nutr, 69(1)61-67 (2021).

 

177) (-)-Epigallocatechin-3-O-gallate at a high concentration may induce lipolysis via ATP consumption by activation of stress defense mechanisms., Satoki Suihara, Akari Ishisaka, Akira Murakami. Biosci. Biotehcnol. Biochem. 85(2) 411-420 (2020).

 

176) Curcumin may induce lipolysis via proteo-stress in Huh7 human hepatoma cells., Valentine C, Ohnishi K, Irie K. Murakami A*, J. Clin. Biochem. Nutr.,65(2):91-98. doi: 10.3164/jcbn.19-7 (2019).

 

175) Covalent modification of phosphatidylethanolamine by benzyl isothiocyanate and consequent generation of ethanolamine-adduct as its metabolites,  Nakamura T, Hirakawa M, Nakamura Y, Ishisaka A, Kitamonot N, Murakami A, Kato Y*, Chem Res Toxicol., 32(4):638-644. doi: 10.1021/acs.chemrestox.8b00331 (2019). PMID: 30735032

 

174) Cytotoxic and cytoprotective effects of tryptamine-4,5-dione on neuronal cells: a double-edged sword. Suga N, Murakami A, Nakamura Y, Ishisaka A, Kitamoto N, Ito M, Kato Y*. Free Radic. Res., 51(5), 545-553 (2017). PMID: 28503967

 

173) Possible contribution of zerumbone-induced proteo-stress to its anti-inflammatory functions via the activation of heat shock factor 1, Igarashi Y, Ohnishi K, Irie K, Murakami A*. PLoS ONE, 18;11(8):e0161282 (2016).PMID: 27536885

 

172) Anthocyanin-rich tea Sunrouge up-regulates expressions of heat shock proteins in the gastrointestinal tract of ICR mice: A comparison with the conventional tea cultivar Yabukita. Murakami A*, Nesumi A, Maeda-Yamamoto M, Yamaguchi H, Yashima K, Miura M, Nakano T, Nekoshima K. J Food Drug Anal.,2015, 23:407-416. 

 

171) Role of ATF3 for ER stress-induced sensitization of p53-deficient human colon cancer cells to TRAIL-mediated apoptosis through up-regulation of DR5 by zerumbone and celecoxib. Edagawa M, Kawauchi J, Hirata M, Goshima H, Inoue M, Murakami A, Maehara Y, Kitajima S*. J Biol Chem. 2014, 289(31):21544-21561. PMID: 24939851

 

170) Novel synthesis of zerumbone-pendant derivatives and their biological activity. Kitayama T*, Nakahira M, Yamazaki K, Inoue H, Imada C, Yonekura Y, Awata H, Kawai Y, Ohnishi K, Murakami A. Tetrahedron. 2013, 69(47):10152-60.

 

169) RANKL signaling and osteoclastogenesis is negatively regulated by cardamonin. Sung B, Prasad S, Yadav VR, Gupta SC, Reuter S. Yamamoto N, Murakami A, Aggarwal BB*. PLoS ONE. 2013 May 17;8(5):e64118. PMID: 23691159

 

168) Structure-activity studies on the side chain of a simplified analog of aplysiatoxin (aplog-1) with anti-proliferative activity. Kamachi H, Tanaka K, Yanagita RC, Murakami A, Murakami K, Tokuda H, Suzuki N, Nakagawa Y, Irie K*., Bioorg Med Chem., 2013 May 15;21(10):2695-702.PMID: 23582444

 

167) Low and medium but not high doses of green tea polyphenols ameliorate dextran sodium sulfate-induced hepatotoxicity and nephrotoxicity. Inoue H, Maeda-Yamamoto M, Nesumi A, Tanaka T,Murakami A*., Biosci Biotechnol Biochem., 2013;77(6):1223-8. PMID:23748761

 

166) Non-specific protein modifications by a phytochemical induce heat shock response for self-defense. Ohnishi K, Ohkura S, Nakahata E, Ishisaka A, Kawai Y, Terao J, Mori T, Ishii T, Nakayama T, Kioka N, Matsumoto S, Ikeda Y, Akiyama M, Irie K, Murakami A*., PLoS ONE, 2013;8(3):e58641. PMID: 23536805

 

165) Zerumbone, an electrophilic sesquiterpene, induces cellular proteo-stress leading to activation of ubiquitine-proteasome system and autophagy. Ohnishi K, Nakahata E, Irie K, Murakami A*., Biochem Biophys Res Commun, 2013 Jan 11;430(2):616-22. PMID: 23219816

 

164) Zerumbone causes Bax and Bak-mediated apoptosis in human breast cancer cells and inhibits orthotonic xenograft growth in vivo. Sehrawat A, Arlotti JA, Murakami A, Singh SV, Breast Cancer Res Treat, 2012 Nov;136(2):429-41. doi:10.1007/s10549-012-2280-5. Epub 2012 Oct 6.PMID: 23053663  

 

163) Glyceraldehyde 3-phosphate dehydrogenase regulates cyclooxygenase-2 expression by targeting mRNA stability, Ikeda Y, Yamaji R, Irie K, Kioka K, Murakami A, Arch Biochem Biophys, 2012 Sep 19;528(2):141-147. PMID: 23000033

162) Curcumin combined with turmerones, essential oil components of turmeric, abolishes inflammation-associated mouse colon carcinogenesis. Murakami A*, Furukawa I, Miyamoto S, Tanaka T, Ohigashi H. Biofactors, 2012 Dec 11. doi: 10.1002/biof.1054. PMID: 23233214 

 

161) Delphinidin-3-O-galactoside protects mouse hepatocytes from (-)-epoigallocatechin-3-gallate-induced cytotoxicity via up-regulation of heme oxygenease-1 and heat shock protein 70. Inoue H, Maeda-Yamamoto M, Nesumi A, Murakami A*. Nutr Res, 2012 May;32(5):357-64.PMID: 22652375

 

160) Auraptene attenuates gastritis via reduction of Helicobactor pylori colonization and proinflammatory mediator production in C57BL/6 mice. Sekiguchi H, Takabayashi F, Irie K, Murakami A*. J Med Food, 2012 Jul;15(7):658-63. PMID: 22471969.

 

159) Identification and biological activities of bryostatins from Japanese bryozoan. Ueno S, Yanagita RC, Murakami K, Murakami A, Tokuda H, Suzuki N, Irie K*.  Biosci Biotechnol Biochem, 2012;76(5):1041-3. PMID: 22738985.

 

158) Chemical analysis and acetylcholinesterase inhibitory effect of anthocyanin-rich red leaf tea (cv. 'Sunrouge'). Maeda-Yamamoto M*, Saito T, Nesumi A, Tokuda Y, Ema K, Honma D, Ogino A, Monobe M, Murakami A, Murakami A, Tachibana H. J Sci Food Agric, 2012 Aug. 30;92(11):2379-86. PMID: 22419270.

 

157) Effects of anthocyanin-rich tea 'Sunrouge' on dextran sodium sulfate-induced colitis in mice. Akiyama S, Nesumi A, Maeda-Yamamoto M, Uehara M, Murakami A*., Biofactors, 2012 Mar16; 38(3):226-33. PMID: 22422705.

 

156) Synthesis and structure–activity studies of simplified analogues of aplysiatoxin with anti-proliferative activity like bryostatin-1. Irie K*, Kikumori M, Kamachi H, Tanaka K, Murakami A, Yanagita RC, Tokuda H, Suzuki N, Nagai H, Suenaga K, Nakagawa Y. Pure Appl Chem., 2012, 84 (6) 1341–1351.

 

155) 1,2-Di-O-alpha-Linolenoyl-3-O-beta-galactosyl-sn-glycerol as a superoxide generation inhibitor from Perilla frutescens var. crispa. Takahashi M, Sugiyama Y, Kawabata K, Takahashi Y, Irie K,Murakami A, Kubo Y, Kobayashi K, Ohigashi H*. Biosci Biotechnol Biochem, 2011;75(11):2240-2. PMID: 22056448.

 

154) High-dose green tea polyphenols induce nephrotoxicity in dextran sulfate sodium-induced colitis mice by down-regulation of antioxidant enzymes and heat shock proteins expressions. Inoue H, Akiyama S, Maeda-Yamamoto, Nesumi A, Tanaka T, Murakami A*. Cell Stress Chaperon, 2011 Nov;16(6):653-62. PMID: 21766215

153) Cardamonin suppresses nitric oxide production via blocking the IFNγ/STAT pathway in endotoxin-challenged peritoneal macrophages of ICR mice. Takahashi A, Yamamoto N, Murakami A*., Life Sci, 2011 Aug 29;89(9-10):337-42. PMID:21784080

152) Synthesis and biological evaluation of the 12,12-dimethyl derivative of Aplog-1, an antiproliferative analogue of tumor-promoting aplysiatoxin. Nakagawa Y, Kikumori M, Yanagita RC,Murakami A, Tokuda H, Nagai H, Irie K*. Biosci Biotechnol Biochem, 2011 Jun 23;75(6):1167-73. PMID: 21670518

151) Zerumbone induces heme oxygenase-1 expression in mouse skin and cultured murine epidermal cells through activation of Nrf2. Shin JW, Ohnishi K, Murakami A, Kundu JK, Na HK, Ohigashi H, Surh YJ*. Cancer Prev Res, 2011 Jun;4(6):860-70.  PMID:21367956

150)  Development of a quantitative bioassay to assess preventive compounds against inflammation-based carcinogenesis. Onuma K, Suenaga Y, Sakaki R, Yoshitome S, Sato Y, Ogawara S, Suzuki S, Kuramitsu M,  Yokoyama H, Murakami A, Hamada J, Nicolson GL, Kobayashi M, Fujii J, F Okada*. Nitric Oxide, 2011 Feb 21.PMID:21345376

149) Cardamonin stimulates glucose uptake through translocation of glucose transporter 4 in L6 myotubes. Yamamoto N*, Kawabata K, Sawada K, Ueda M, Fukuda I, Kawasaki K, Murakami A, Ashida H. Phytother Res, 2011 Feb 9. doi: 10.1002/ptr.3416.. PMID: 21305634

 

148) Effects of selected food phytochemicals in reducing the toxic actions of TCDD and p,p'-DDT in U937 macrophages. Sciullo EM, Vogel CF, Wu D, Murakami A, Ohigashi H, Matsumura F*.

Arch Toxicol.,2010 Dec;84(12):957-66. PMID: 20865247 

147) Role of the phenolic hydroxyl group in the biological activities of a simplified analogue of aplysiatoxin with antiproliferative activity. Yanagita RC, Kamachi H, Tanaka K, Murakami A, Nakagawa Y, Tokuda H, Nagai H, Irie K*. Bioorg Med Chem Lett, 2010 Oct 15;20(20):6064-6. PMID: 20817520

146) Anti-tumour promoting activity of some Malaysian traditional vegetables (ulam). Lim YM*, Ali AM, Norhanom AB, Mat Salleh K, Murakami A, Koshimizu K. Nat Prod Sci, 1999; 5(1):33-38.

145) Suppressive properties of extracts from Japanese edible plants regarding nitric oxide generation. Lee JK, Murakami A, Watanabe S, Ohigashi H*. Asian Pac J Cancer Prev. 2009 Apr-Jun;10(2):263-72.PMID: 19537895

144) Down-regulation of programmed cell death 4 by inflammatory conditions contributes to the generation of the tumor promoting microenvironment. Yasuda M#, Schmid T#, Rubsamen D, Colburn NH, Irie K, Murakami A* (#equally contributed). Mol Carcinog, 2010 Sep;49(9):837-48. PMID: 20607724

20 articles in Molecular Carcinogenesis most down-loaded during 2009 (345 downloads recorded)

143) Genistein inhibits lipopolysaccharide-induced down-regulation of programmed cell death 4 in RAW 264.7 mouse macrophages. Yasuda M, Irie K, Murakami A*. Biosci Biotechnol Biochem,2010;74(5):1095-7.PMID: 20460704

142) Auraptene suppresses Helicobacter pylori adhesion and IL-8 production via targeting ERK 1/2-dependent CD74 expression in NCI-N87 gastric carcinoma cells. Sekiguchi H, Irie K, Murakami A*. Biosci Biotechnol Biochem,2010;74(5):1018-24.PMID: 20460732

141) Increased visceral fat mass and insulin signaling in colitis-related colon carcinogenesis model mice. Miyamoto S, Tanaka T, Murakami A*., Chem Biol Interact, 2010 Jan 27;183(2):271-5. PMID: 19931517

140') Reply to letter to the editor "Comment on: Dietary flavonoids suppress azoxymethane-induced colonic preneoplastic lesions in male C57BL/Ksj-db/db mice" Miyamoto S, Yasui Y, Ohigashi H, Tanaka T, Murakami A*., Chem Biol Interact, 2010 Jan 27;183(2):271-5. PMID: 19931517.

140) Dietary flavonoids suppress azoxymethane-induced colonic preneoplastic lesions in male C57BL/KsJ-db/db mice. Miyamoto S, Yasui Y, Ohigashi H, Tanaka T, Murakami A*., Chem Biol Interact, 2010 Jan 27;183(2):276-83. PMID: 19914226.

139) The modifying effects of green tea polyphenols on acute colitis and inflammation-associated colon carcinogenesis in male ICR mice. Kim M, Miyamoto S, Ohigashi H, Tanaka T, Murakami A*., Biofactors, 2010 Jan;36(1):43-51.PMID: 20108331

138) Phenethyl isothiocyanate suppresses nitric oxide production via inhibition of PI3K/Akt-induced IFN-gamma secretion in LPS-activated peritoneal macrophages. Ohkubo T, Washida K., Murakami A*. Mol Nutr Food Res, 2010 Sep;54(9):1351-60. PMID: 20229527

137) In vitro covalent binding proteins of zerumbone, a chemopreventive food factor. Ohnishi K, Irie K,Murakami A*. Biosic Biotechnol Biochem, 2009 Aug;73(8):1905-7. PMID: 19661711

 

136) A simple analog of tumor-promoting aplysiatoxin is an antineoplastic agent rather than a tumor promoter: Development of a synthetically accessible PKC activator with bryostatin-like activity. Nakagawa Y, Yanagita R, Hamada N, Murakami A, Takahashi H, Saito N, Nagai H, Irie K*. J Am Chem Soc.,  2009 Jun 10;131(22):7573-9. PMID: 19449873

 

135) Linoleic acid metabolite suppresses skin inflammation and tumor promotion in mice: Possible roles of programmed cell death 4 induction. Yasuda M, Nishizawa T, Ohigashi H, Tanaka T, Hou DX, Colburn NH, Murakami A*. Carcinogenesis, 2009 Jul;30(7):1209-16.PMID: 19414503

 

133) A tobacco-specific carcinogen, NNK, enhances AOM/DSS-induced colon carcinogenesis in male A/J mice.Kim M, Miyamoto S, Sugie S, Yasui Y, Ishigamori-Suzuki R, Murakami A, Nakagama H, Tanaka T*.In Vivo. 2008 Sep-Oct;22(5):557-63.PMID: 18853746

 

132) Zerumbone, a tropical ginger sesquiterpene, inhibits colon and lung carcinogenesis in mice.Kim M, Miyamoto S, Yasui Y, Oyama T, Murakami A, Tanaka T*.Int J Cancer. 2009 Jan 15;124(2):264-71.PMID: 19003968

 

131) Strain differences regarding susceptibility to ursolic acid-induced interleukin-1beta release in murine macrophages.Ikeda Y, Murakami A, Ohigashi H*. Life Sci. 2008 Jul 4;83(1-2):43-9. Epub 2008 May 13.PMID: 18538348

 

130) Suppressive effects of nobiletin on hyperleptinemia and colitis-related colon carcinogenesis in male ICR mice.Miyamoto S, Yasui Y, Tanaka T, Ohigashi H, Murakami A*. Carcinogenesis. 2008 May;29(5):1057-63. Epub 2008 Mar 28.PMID: 18375960

 

129) Suppressive effects of selected food phytochemicals on CD74 expression in NCI-N87 gastric carcinoma cells.Sekiguchi H, Washida K, Murakami A*.J Clin Biochem Nutr. 2008 Sep;43(2):109-17.PMID: 18818744

 

128) Mutagenicity of 8-nitroguanosine, a product of nitrative nucleoside modification by reactive nitrogen oxides, in mammalian cells.Kaneko K, Akuta T, Sawa T, Kim HW, Fujii S, Okamoto T, Nakayama H, Ohigashi H, Murakami A, Akaike T*.Cancer Lett. 2008 Apr 18;262(2):239-47. Epub 2008 Jan 11.PMID: 18248787

 

127) 1'-Acetoxychavicol acetate-induced cytotoxicity is accompanied by a rapid and drastic modulation of glutathione metabolism.Higashida M, Xu S, Kojima-Yuasa A, Kennedy DO, Murakami A, Ohigashi H, Matsui-Yuasa I*. Amino Acids. 2008 Feb 12. [Epub ahead of print]PMID: 18266054

 

126) A novel rasH2 mouse carcinogenesis model that is highly susceptible to 4-NQO-induced tongue and esophageal carcinogenesis is useful for preclinical chemoprevention studies.Miyamoto S, Yasui Y, Kim M, Sugie S, Murakami A, Ishigamori-Suzuki R, Tanaka T*. Carcinogenesis. 2008 Feb;29(2):418-26. Epub 2008 Jan 3.PMID: 18174262

 

125) Metabolism and absorption of auraptene (7-geranyloxylcoumarin) in male SD rats: comparison with 7-ethoxycoumarin.Kuki W, Hosotani K, Ohigashi H, Murakami A*.Nutr Cancer. 2008 May-Jun;60(3):368-72.PMID: 18444171

 

124) Suppressive effects of demethylated metabolites of nobiletin on phorbol ester-induced expression of scavenger receptor genes in THP-1 human monocytic cells.Eguchi A, Murakami A, Li S, Ho CT, Ohigashi H*.Biofactors. 2007;31(2):107-16.PMID: 18806314

 

123) Direct interaction of Cucurbitacin E isolated from Alsomitra macrocarpa to actin filament.Momma K, Masuzawa Y, Nakai N, Chujo M, Murakami A, Kioka N, Kiyama Y, Akita T, Nagao M*.Cytotechnology. 2008 Jan;56(1):33-9. Epub 2007 Nov 7.PMID: 19002839

 

122) Citrus nobiletin suppresses bone loss in ovariectomized ddY mice and collagen-induced arthritis in DBA/1J mice: possible involvement of receptor activator of NF-kappaB ligand (RANKL)-induced osteoclastogenesis regulation.Murakami A, Song M, Katsumata S, Uehara M, Suzuki K, Ohigashi H*.Biofactors. 2007;30(3):179-92.PMID: 18525112

 

121) Phenethyl isothiocyanate suppresses receptor activator of NF-kappaB ligand (RANKL)-induced osteoclastogenesis by blocking activation of ERK1/2 and p38 MAPK in RAW264.7 macrophages.Murakami A, Song M, Ohigashi H*.Biofactors. 2007;30(1):1-11.PMID: 18198396

 

120) Lack of enhancing effect of lauric acid on the development of aberrant crypt foci in male ICR mice treated with azoxymethane and dextran sodium sulfateS. Miyamoto, R. Suzuki, Y. Yasui, H. Kohno, S. Sugie, A. Murakami, H. Ohigashi, T. Tanaka*., J Toxicol Pathol, 2007, 20, 93-100.

 

119) Modifying effects of dietary factors on (-)-epigallocatechin-3-gallate-induced pro-matrix metalloproteinase-7 production in HT-29 human colorectal cancer cells.Kim M, Murakami A, Ohigashi H*.Biosci Biotechnol Biochem. 2007 Oct;71(10):2442-50. Epub 2007 Oct 7.PMID: 17928719

Biosci Biotechnol Biochem論文賞

 

118) Dextran sulfate sodium enhances interleukin-1 beta release via activation of p38 MAPK and ERK1/2 pathways in murine peritoneal macrophages.Kwon KH, Ohigashi H, Murakami A*.Life Sci. 2007 Jul 12;81(5):362-71. Epub 2007 Jun 13.PMID: 17628610

 

117) Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism.Sandur SK, Pandey MK, Sung B, Ahn KS, Murakami A, Sethi G, Limtrakul P, Badmaev V, Aggarwal BB*.Carcinogenesis. 2007 Aug;28(8):1765-73. Epub 2007 May 23.PMID: 17522064

 

116) Aggregated ursolic acid, a natural triterpenoid, induces IL-1beta release from murine peritoneal macrophages: role of CD36.Ikeda Y, Murakami A, Fujimura Y, Tachibana H, Yamada K, Masuda D, Hirano K, Yamashita S, Ohigashi H*.J Immunol. 2007 Apr 15;178(8):4854-64.PMID: 17404266

 

115) Zerumbone suppresses phorbol ester-induced expression of multiple scavenger receptor genes in THP-1 human monocytic cells.Eguchi A, Kaneko Y, Murakami A, Ohigashi H*.Biosci Biotechnol Biochem. 2007 Apr;71(4):935-45. Epub 2007 Apr 7.PMID: 17420607

 

114) Cellular thiol status-dependent inhibition of tumor cell growth via modulation of p27(kip1) translocation and retinoblastoma protein phosphorylation by 1'-acetoxychavicol acetate. Unahara Y, Kojima-Yuasa A, Higashida M, Kennedy DO, Murakami A, Ohigashi H, Matsui-Yuasa I*.Amino Acids. 2007 Sep;33(3):469-76. Epub 2006 Oct 10.PMID: 17031475

 

113) Zerumbone, a bioactive sesquiterpene, induces G2/M cell cycle arrest and apoptosis in leukemia cells via a Fas- and mitochondria-mediated pathway.Xian M, Ito K, Nakazato T, Shimizu T, Chen CK, Yamato K, Murakami A, Ohigashi H, Ikeda Y, Kizaki M*.Cancer Sci. 2007 Jan;98(1):118-26.PMID: 17129359

 

112) Citrus auraptene targets translation of MMP-7 (matrilysin) via ERK1/2-dependent and mTOR-independent mechanism.Kawabata K, Murakami A, Ohigashi H*.FEBS Lett. 2006 Oct 2;580(22):5288-94. Epub 2006 Sep 11.PMID: 16979634

 

111) Auraptene decreases the activity of matrix metalloproteinases in dextran sulfate sodium-induced ulcerative colitis in ICR mice.Kawabata K, Murakami A, Ohigashi H*.Biosci Biotechnol Biochem. 2006 Dec;70(12):3062-5. Epub 2006 Dec 7.PMID: 17151446

 

110) Nobiletin, a citrus flavonoid, suppresses phorbol ester-induced expression of multiple scavenger receptor genes in THP-1 human monocytic cells.Eguchi A, Murakami A, Ohigashi H*.FEBS Lett. 2006 May 29;580(13):3321-8. Epub 2006 May 4.PMID: 16698017

 

109) 1'-Acetoxychavicol acetate inhibits RANKL-induced osteoclastic differentiation of RAW 264.7 monocytic cells by suppressing nuclear factor-kappaB activation.Ichikawa H, Murakami A, Aggarwal BB*.Mol Cancer Res. 2006 Apr;4(4):275-81.PMID: 16603641

 

108) Preventive effects of chrysin on the development of azoxymethane-induced colonic aberrant crypt foci in rats.Miyamoto S, Kohno H, Suzuki R, Sugie S, Murakami A, Ohigashi H, Tanaka T*.Oncol Rep. 2006 May;15(5):1169-73.PMID: 16596181

 

107) Suppressive effects of Okinawan food items on free radical generation from stimulated leukocytes and identification of some active constituents: implications for the prevention of inflammation-associated carcinogenesis.Murakami A, Ishida H, Kobo K, Furukawa I, Ikeda Y, Yonaha M, Aniya Y, Ohigashi H*.Asian Pac J Cancer Prev. 2005 Oct-Dec;6(4):437-48.PMID: 16435988

 

106) Ursolic acid enhances cyclooxygenases and tumor necrosis factor-alpha expression in mouse skin.Ikeda Y, Murakami A, Nishizawa T, Ohigashi H*.Biosci Biotechnol Biochem. 2006 Apr;70(4):1033-7.PMID: 16636478

 

105) 1'-Acetoxychavicol acetate induces apoptosis of myeloma cells via induction of TRAIL.Ito K, Nakazato T, Murakami A, Ohigashi H, Ikeda Y, Kizaki M*.Biochem Biophys Res Commun. 2005 Dec 30;338(4):1702-10. Epub 2005 Nov 2.PMID: 16289031

 

104) Suppressive effects of mioga ginger and ginger constituents on reactive oxygen and nitrogen species generation, and the expression of inducible pro-inflammatory genes in macrophages.Kim HW,Murakami A, Abe M, Ozawa Y, Morimitsu Y, Williams MV, Ohigashi H*.Antioxid Redox Signal. 2005 Nov-Dec;7(11-12):1621-9.PMID: 16356125

 

103) Interleukin-1beta targets interleukin-6 in progressing dextran sulfate sodium-induced experimental colitis.Kwon KH, Murakami A, Hayashi R, Ohigashi H*.Biochem Biophys Res Commun. 2005 Nov 18;337(2):647-54. Epub 2005 Sep 26.PMID: 16202978

 

102) Growth inhibitory activities of crude extracts obtained from herbal plants in the Ryukyu Islands on several human colon carcinoma cell lines.Kaneshiro T, Suzui M, Takamatsu R, Murakami A, Ohigashi H, Fujino T, Yoshimi N*.Asian Pac J Cancer Prev. 2005 Jul-Sep;6(3):353-8.PMID: 16235999

 

101) Zingiberaceous and citrus constituents, 1'-acetoxychavicol acetate, zerumbone, auraptene, and nobiletin, suppress lipopolysaccharide-induced cyclooxygenase-2 expression in RAW264.7 murine macrophages through different modes of action.Murakami A, Shigemori T, Ohigashi H*.J Nutr. 2005 Dec;135(12 Suppl):2987S-2992S.PMID: 16317159

 

100) Ursolic acid promotes the release of macrophage migration inhibitory factor via ERK2 activation in resting mouse macrophages.Ikeda Y, Murakami A, Ohigashi H*.Biochem Pharmacol. 2005 Nov 15;70(10):1497-505. Epub 2005 Sep 26.PMID: 16188240

 

99) New class of linoleic acid metabolites biosynthesized by corn and rice lipoxygenases: suppression of proinflammatory mediator expression via attenuation of MAPK- and Akt-, but not PPARgamma-, dependent pathways in stimulated macrophages.Murakami A, Nishizawa T, Egawa K, Kawada T, Nishikawa Y, Uenakai K, Ohigashi H*.Biochem Pharmacol. 2005 Nov 1;70(9):1330-42.PMID: 16143312

 

98) Zerumbone abolishes NF-kappaB and IkappaBalpha kinase activation leading to suppression of antiapoptotic and metastatic gene expression, upregulation of apoptosis, and downregulation of invasion.Takada Y, Murakami A, Aggarwal BB*.Oncogene. 2005 Oct 20;24(46):6957-69.PMID: 16007145

 

97) Identification of a novel blocker of I kappa B alpha kinase that enhances cellular apoptosis and inhibits cellular invasion through suppression of NF-kappa B-regulated gene products.Ichikawa H, Takada Y, Murakami A, Aggarwal BB*.J Immunol. 2005 Jun 1;174(11):7383-92.PMID: 15905586

 

96) (-)-Epigallocatechin-3-gallate promotes pro-matrix metalloproteinase-7 production via activation of the JNK1/2 pathway in HT-29 human colorectal cancer cells.Kim M, Murakami A, Kawabata K, Ohigashi H*.Carcinogenesis. 2005 Sep;26(9):1553-62. Epub 2005 Apr 28.PMID: 15860507

 

95) 1'-Acetoxychavicol acetate is a novel nuclear factor kappaB inhibitor with significant activity against multiple myeloma in vitro and in vivo.Ito K, Nakazato T, Xian MJ, Yamada T, Hozumi N,Murakami A, Ohigashi H, Ikeda Y, Kizaki M*.Cancer Res. 2005 May 15;65(10):4417-24.PMID: 15899834

 

94) Novel bioassay system for evaluating anti-oxidative activities of food items: use of basolateral media from differentiated Caco-2 cells.Eguchi A, Murakami A, Ohigashi H*.Free Radic Res. 2005 Dec;39(12):1367-75.PMID: 16298867

 

93) Suppression of beta-catenin mutation by dietary exposure of auraptene, a citrus antioxidant, in N,N-diethylnitrosamine-induced hepatocellular carcinomas in rats.Hara A, Sakata K, Yamada Y, Kuno T, Kitaori N, Oyama T, Hirose Y, Murakami A, Tanaka T, Mori H*.Oncol Rep. 2005 Aug;14(2):345-51.PMID: 16012713

 

92) Nobiletin, a citrus flavonoid, down-regulates matrix metalloproteinase-7 (matrilysin) expression in HT-29 human colorectal cancer cells.Kawabata K, Murakami A, Ohigashi H*.Biosci Biotechnol Biochem. 2005 Feb;69(2):307-14.PMID: 15725655

 

91) Dietary rutin, but not its aglycone quercetin, ameliorates dextran sulfate sodium-induced experimental colitis in mice: attenuation of pro-inflammatory gene expression.Kwon KH, Murakami A, Tanaka T, Ohigashi H*.Biochem Pharmacol. 2005 Feb 1;69(3):395-406. Epub 2004 Dec 15.PMID: 15652231 

This manuscript has been rated as one of the top 1 percent in terms of downloads among all articles published in the journal over the past decade.

90) Citrus nobiletin inhibits azoxymethane-induced large bowel carcinogenesis in rats.Suzuki R, Kohno H, Murakami A, Koshimizu K, Ohigashi H, Yano M, Tokuda H, Nishino H, Tanaka T*.Biofactors. 2004;22(1-4):111-4.PMID: 15751122

 

89) Zerumbone, a tropical ginger sesquiterpene, activates phase II drug metabolizing enzymes.Nakamura Y, Yoshida C, Murakami A, Ohigashi H, Osawa T, Uchida K*.FEBS Lett. 2004 Aug 13;572(1-3):245-50.PMID: 15304356

 

88) Modifying effects of 1'-acetoxychavicol acetate (ACA) and the novel synthetic retinoids Re-80, Am-580 and Am-55P in a two-stage carcinogenesis model in female rats.Orita S, Hirose M, Takahashi S, Imaida K, Ito N, Shudo K, Ohigashi H, Murakami A, Shirai T*.Toxicol Pathol. 2004 Mar-Apr;32(2):250-7.PMID: 15200164

 

87) Suppressive activity of a fermented grain food product on dextran sulfate sodium-induced experimental colitis in mice.Kwon KH, Murakami A, Tanaka T, Ohigashi H*.Biofactors. 2004;21(1-4):179-84.PMID: 15630159

 

86) Zerumbone, an anti-inflammatory phytochemical, induces expression of proinflammatory cytokine genes in human colon adenocarcinoma cell lines.Murakami A, Miyamoto M, Ohigashi H*.Biofactors. 2004;21(1-4):95-101.PMID: 15630177

 

85) Induction of apoptosis in human myeloid leukemic cells by 1'-acetoxychavicol acetate through a mitochondrial- and Fas-mediated dual mechanism.Ito K, Nakazato T, Murakami A, Yamato K, Miyakawa Y, Yamada T, Hozumi N, Ohigashi H, Ikeda Y, Kizaki M*.Clin Cancer Res. 2004 Mar 15;10(6):2120-30.PMID: 15041733

 

84) Zerumbone, a sesquiterpene in subtropical ginger, suppresses skin tumor initiation and promotion stages in ICR mice.Murakami A, Tanaka T, Lee JY, Surh YJ, Kim HW, Kawabata K, Nakamura Y, Jiwajinda S, Ohigashi H*.Int J Cancer. 2004 Jul 1;110(4):481-90.PMID: 15122579

 

83) Dietary supplementation of the citrus antioxidant auraptene inhibits N,N-diethylnitrosamine-induced rat hepatocarcinogenesis.Sakata K, Hara A, Hirose Y, Yamada Y, Kuno T, Katayama M, Yoshida K, Zheng Q, Murakami A, Ohigashi H, Ikemoto K, Koshimizu K, Tanaka T, Mori H*.Oncology. 2004;66(3):244-52.PMID: 15218316

 

82) Suppressive effects of natural and synthetic agents on dextran sulfate sodium-induced interleukin-1beta release from murine peritoneal macrophages.Kwon KH, Murakami A, Ohigashi H*.Biosci Biotechnol Biochem. 2004 Feb;68(2):436-9.PMID: 14981311

 

81) Suppressive effects of selected antioxidants on the activated leukocytes-induced mutagenesis in the co-culture assay systems.Kim HW, Murakami A, Williams MV, Ohigashi H*.Biosci Biotechnol Biochem. 2004 Jan;68(1):238-42.PMID: 14745192

 

80) Antioxidant activity in vitro of two aromatic compounds from Caesalpinia sappan L.Safitri R, Tarigan P, Freisleben HJ, Rumampuk RJ, Murakami A*.Biofactors. 2003;19(1-2):71-7.PMID: 14757979

 

79) Characteristic rat tissue accumulation of nobiletin, a chemopreventive polymethoxyflavonoid, in comparison with luteolin.Murakami A, Koshimizu K, Ohigashi H, Kuwahara S, Kuki W, Takahashi Y, Hosotani K, Kawahara S, Matsuoka Y*.Biofactors. 2002;16(3-4):73-82.PMID: 14530595

 

78) Suppression of dextran sodium sulfate-induced colitis in mice by zerumbone, a subtropical ginger sesquiterpene, and nimesulide: separately and in combination.Murakami A*, Hayashi R, Tanaka T, Kwon KH, Ohigashi H, Safitri R.Biochem Pharmacol. 2003 Oct 1;66(7):1253-61. Erratum in: Biochem Pharmacol. 2004 Jan 15;67(2):395. Takana Takuji [corrected to Tanakja Takuji]. PMID: 14505804

 

77) Combinatorial effects of nonsteroidal anti-inflammatory drugs and food constituents on production of prostaglandin E2 and tumor necrosis factor-alpha in RAW264.7 murine macrophages.Murakami A, Takahashi D, Hagihara K, Koshimizu K, Ohigashi H*.Biosci Biotechnol Biochem. 2003 May;67(5):1056-62.PMID: 12834283

 

76) Effects of selected food factors with chemopreventive properties on combined lipopolysaccharide- and interferon-gamma-induced IkappaB degradation in RAW264.7 macrophages.Murakami A, Matsumoto K, Koshimizu K, Ohigashi H*.Cancer Lett. 2003 May 30;195(1):17-25.PMID: 12767507

 

75) A phase II detoxification enzyme inducer from lemongrass: identification of citral and involvement of electrophilic reaction in the enzyme induction.Nakamura Y, Miyamoto M, Murakami A, Ohigashi H, Osawa T, Uchida K*.Biochem Biophys Res Commun. 2003 Mar 14;302(3):593-600.PMID: 12615076

 

74) Mutagenicity of reactive oxygen and nitrogen species as detected by co-culture of activated inflammatory leukocytes and AS52 cells.Kim HW, Murakami A, Williams MV, Ohigashi H*.Carcinogenesis. 2003 Feb;24(2):235-41.PMID: 12584172

 

73) Synergistic suppression of superoxide and nitric oxide generation from inflammatory cells by combined food factors.Murakami A, Takahashi D, Koshimizu K, Ohigashi H*.Mutat Res. 2003 Feb-Mar;523-524:151-61.PMID: 12628513

 

72) Suppressive effects of edible Thai plants on superoxide and nitric oxide generation.Jiwajinda S, Santisopasri V, Murakami A, Kim OK, Kim HW, Ohigashi H*.Asian Pac J Cancer Prev. 2002;3(3):215-223.PMID: 12718578

 

71) Further investigation of the modifying effect of various chemopreventive agents on apoptosis and cell proliferation in human colon cancer cells.Zheng Q, Hirose Y, Yoshimi N, Murakami A, Koshimizu K, Ohigashi H, Sakata K, Matsumoto Y, Sayama Y, Mori H*.J Cancer Res Clin Oncol. 2002 Oct;128(10):539-46. Epub 2002 Sep 17.PMID: 12384797

 

70) In vitro anti-tumor promoting and anti-parasitic activities of the quassinoids from Eurycoma longifolia, a medicinal plant in Southeast Asia.Jiwajinda S, Santisopasri V, Murakami A, Sugiyama H, Gasquet M, Riad E, Balansard G, Ohigashi H*.J Ethnopharmacol. 2002 Sep;82(1):55-8. Erratum in: J Ethnopharmacol.2003 Mar;85(1):173. PMID: 12169407 

 

69') Redox-regulated mechanism may account for zerumbone's ability to suppress cancer-cell proliferation.Hoffman A, Spetner LM, Burke M.Carcinogenesis. 2002 Nov;23(11):1961; author reply1963.PMID: 12419847

 

69) Zerumbone, a Southeast Asian ginger sesquiterpene, markedly suppresses free radical generation, proinflammatory protein production, and cancer cell proliferation accompanied by apoptosis: the alpha,beta-unsaturated carbonyl group is a prerequisite.Murakami A, Takahashi D, Kinoshita T, Koshimizu K, Kim HW, Yoshihiro A, Nakamura Y, Jiwajinda S, Terao J, Ohigashi H*.Carcinogenesis. 2002 May;23(5):795-802. PMID: 12016152

 

68) FA15, a hydrophobic derivative of ferulic acid, suppresses inflammatory responses and skin tumor promotion: comparison with ferulic acid.Murakami A, Nakamura Y, Koshimizu K, Takahashi D, Matsumoto K, Hagihara K, Taniguchi H, Nomura E, Hosoda A, Tsuno T, Maruta Y, Kim HW, Kawabata K, Ohigashi H*.Cancer Lett. 2002 Jun 28;180(2):121-9.PMID: 12175542

 

67) Involvement of protein tyrosine phosphorylation and reduction of cellular sulfhydryl groups in cell death induced by 1' -acetoxychavicol acetate in Ehrlich ascites tumor cells.Moffatt J, Kennedy DO, Kojima A, Hasuma T, Yano Y, Otani S, Murakami A, Koshimizu K, Ohigashi H, Matsui-Yuasa I*.Chem Biol Interact. 2002 Feb 20;139(2):215-30.PMID: 11823008

 

66) Synthesis of novel polyphenols consisted of ferulic and gallic acids, and their inhibitory effects on phorbol ester-induced Epstein-Barr virus activation and superoxide generation.Nomura E, Hosoda A, Morishita H, Murakami A, Koshimizu K, Ohigashi H, Taniguchi H*.Bioorg Med Chem. 2002 Apr;10(4):1069-75.PMID: 11836117

 

65) Synthesis of feruloyl-myo-insitol derivatives and their inhibitory effects on phorbol ester-induced superoxide generation and Esptein-Barr virus activation.Hosoda A, Nomura E, Murakami A, Koshimizu K, Ohigashi H, Mizuno K, Taniguchi H*.Bioorg Med Chem. 2002 Jun;10(6):1855-63.PMID: 11937343

 

64) Screening of edible Japanese plants for suppressive effects on phorbol ester-induced superoxide generation in differentiated HL-60 cells and AS52 cells.Kim HW, Murakami A, Nakamura Y, Ohigashi H*.Cancer Lett. 2002 Feb 8;176(1):7-16.PMID: 11790448

 

63) Rapid and convenient method for preparing aurapten-enriched product from hassaku peel oil: implications for cancer-preventive food additives.Takahashi Y, Inaba N, Kuwahara S, Kuki W, Yamane K, Murakami A*.J Agric Food Chem. 2002 May 22;50(11):3193-6.PMID: 12009985

 

62) In vitro absorption and metabolism of nobiletin, a chemopreventive polymethoxyflavonoid.Murakami A, Kuwahara S, Takahashi Y, Ito C, Furukawa H, Ju-Ichi M, Koshimizu K*. Biosci Biotechnol BIochem. 2001 Jan; 65(1):194-7. PMID: 11272829

 

61) Anti-tumor promoting activity of bufadienolides from Kalanchoe pinnata and K. daigremontiana x tubiflora.Supratman U, Fujita T, Akiyama K, Hayashi H, Murakami A, Sakai H, Koshimizu K, Ohigashi H*.Biosci Biotechnol Biochem. 2001 Apr;65(4):947-9.PMID: 11388478

 

60) Ligands for peroxisome proliferator-activated receptors alpha and gamma inhibit chemically induced colitis and formation of aberrant crypt foci in rats.Tanaka T*, Kohno H, Yoshitani S, Takashima S, Okumura A, Murakami A, Hosokawa M.Cancer Res. 2001 Mar 15;61(6):2424-8.PMID: 11289109

 

59) Dietary administration of citrus nobiletin inhibits azoxymethane-induced colonic aberrant crypt foci in rats.Kohno H, Yoshitani S, Tsukio Y, Murakami A, Koshimizu K, Yano M, Tokuda H, Nishino H, Ohigashi H, Tanaka T*.Life Sci. 2001 Jul 13;69(8):901-13.PMID: 11488403

 

58) Chemoprevention of azoxymethane-induced rat aberrant crypt foci by dietary zerumbone isolated from Zingiber zerumbet.Tanaka T, Shimizu M, Kohno H, Yoshitani S, Tsukio Y, Murakami A, Safitri R, Takahashi D, Yamamoto K, Koshimizu K, Ohigashi H, Mori H*.Life Sci. 2001 Sep 7;69(16):1935-45.PMID: 11693274 

 

57) Quassinoids from Eurycoma longifolia as plant growth inhibitors. Jiwajinda S, Santisopasri V,Murakami A, Hirai N, Ohigashi H*. Phytochemistry 2001 Nov;58(6):959-62. PMID: 11684195

 

56) Apoptosis induced by 1'-acetoxychavicol acetate in Ehrlich ascites tumor cells is associated with modulation of polyamine metabolism and caspase-3 activation.Moffatt J, Hashimoto M, Kojima A, Kennedy DO, Murakami A, Koshimizu K, Ohigashi H, Matsui-Yuasa I*.Carcinogenesis. 2000 Dec;21(12):2151-7.PMID: 11133803

 

55) Nitric oxide synthase is induced in tumor promoter-sensitive, but not tumor promoter-resistant, JB6 mouse epidermal cells cocultured with interferon-gamma-stimulated RAW 264.7 cells: the role of tumor necrosis factor-alpha.Murakami A, Kawabata K, Koshiba T, Gao G, Nakamura Y, Koshimizu K, Ohigashi H*.Cancer Res. 2000 Nov 15;60(22):6326-31.PMID: 11103793

 

54) An avocado constituent, persenone A, suppresses expression of inducible forms of nitric oxide synthase and cyclooxygenase in macrophages, and hydrogen peroxide generation in mouse skin.Kim OK, Murakami A, Takahashi D, Nakamura Y, Torikai K, Kim HW, Ohigashi H*.Biosci Biotechnol Biochem. 2000 Nov;64(11):2504-7.PMID: 11193428

 

53) Inhibition by (-)-persenone A-related compounds of nitric oxide and superoxide generation from inflammatory leukocytes.Kim OK, Murakami A, Nakamura Y, Kim HW, Ohigash H*.Biosci Biotechnol Biochem. 2000 Nov;64(11):2500-3.PMID: 11193427

 

52) A glutathione S-transferase inducer from papaya: rapid screening, identification and structure-activity relationship of isothiocyanates.Nakamura Y, Morimitsu Y, Uzu T, Ohigashi H, Murakami A, Naito Y, Nakagawa Y, Osawa T, Uchida K*.Cancer Lett. 2000 Sep 1;157(2):193-200.PMID: 10936680

 

51) A simple phenolic antioxidant protocatechuic acid enhances tumor promotion and oxidative stress in female ICR mouse skin: dose-and timing-dependent enhancement and involvement of bioactivation by tyrosinase.Nakamura Y, Torikai K, Ohto Y, Murakami A, Tanaka T, Ohigashi H*.Carcinogenesis. 2000 Oct;21(10):1899-907.PMID: 11023549

 

50) Suppression by citrus auraptene of phorbol ester-and endotoxin-induced inflammatory responses: role of attenuation of leukocyte activation.Murakami A, Nakamura Y, Tanaka T, Kawabata K, Takahashi D, Koshimizu K, Ohigashi H*.Carcinogenesis. 2000 Oct;21(10):1843-50.PMID: 11023542

 

49) Inhibitory effects of 1'-acetoxychavicol acetate on N-Nitrosobis(2-oxopropyl)-amine-induced initiation of cholangiocarcinogenesis in Syrian hamsters.Miyauchi M, Nishikawa A, Furukawa F, Nakamura H, Son HY, Murakami A, Koshimizu K, Ohigashi H, Hirose M*.Jpn J Cancer Res. 2000 May;91(5):477-81.PMID: 10835491

 

48) Synthesis of feruloyl-myo-inositols and their inhibitory effects on superoxide generation.Hosoda A, Nomura E, Murakami A, Koshimizu K, Ohigashi H, Mizuno K, Taniguchi H*.Bioorg Med Chem Lett. 2000 Jul 3;10(13):1439-42.PMID: 10888327

 

47) Inhibitory effect of citrus nobiletin on phorbol ester-induced skin inflammation, oxidative stress, and tumor promotion in mice.Murakami A, Nakamura Y, Torikai K, Tanaka T, Koshiba T, Koshimizu K, Kuwahara S, Takahashi Y, Ogawa K, Yano M, Tokuda H, Nishino H, Mimaki Y, Sashida Y, Kitanaka S, Ohigashi H*.Cancer Res. 2000 Sep 15;60(18):5059-66.PMID: 11016629

 

46) Suppressive effects of novel ferulic acid derivatives on cellular responses induced by phorbol ester, and by combined lipopolysaccharide and interferon-gamma.Murakami A, Kadota M, Takahashi D, Taniguchi H, Nomura E, Hosoda A, Tsuno T, Maruta Y, Ohigashi H, Koshimizu K*.Cancer Lett. 2000 Aug 31;157(1):77-85.PMID: 10893445

 

45) Prevention of colonic aberrant crypt foci by dietary feeding of garcinol in male F344 rats.Tanaka T, Kohno H, Shimada R, Kagami S, Yamaguchi F, Kataoka S, Ariga T, Murakami A, Koshimizu K, Ohigashi H*.Carcinogenesis. 2000 Jun;21(6):1183-9.PMID: 10837008

 

44) Suppressive effects of citrus fruits on free radical generation and nobiletin, an anti-inflammatory polymethoxyflavonoid.Murakami A, Nakamura Y, Ohto Y, Yano M, Koshiba T, Koshimizu K, Tokuda H, Nishino H, Ohigashi H*.Biofactors. 2000;12(1-4):187-92.PMID: 11216485

 

43) Suppression of N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis by dietary feeding of auraptene.Kawabata K, Tanaka T, Yamamoto T, Hara A, Murakami A, Koshimizu K, Ohigashi H, Stoner GD, Mori H*.J Exp Clin Cancer Res. 2000 Mar;19(1):45-52.PMID: 10840935

 

42) Novel nitric oxide and superoxide generation inhibitors, persenone A and B, from avocado fruit.Kim OK, Murakami A, Nakamura Y, Takeda N, Yoshizumi H, Ohigashi H*.J Agric Food Chem. 2000 May;48(5):1557-63.PMID: 10820058

 

41) Suppression of N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis by dietary feeding of 1'-acetoxychavicol acetate.Kawabata K, Tanaka T, Yamamoto T, Ushida J, Hara A,Murakami A, Koshimizu K, Ohigashi H, Stoner GD, Mori H*.Jpn J Cancer Res. 2000 Feb;91(2):148-55.PMID: 10761701

 

40) Structure-activity relationships of (1'S)-1'-acetoxychavicol acetate, a major constituent of a southeast Asian condiment plant Languas galanga, on the inhibition of tumor-promoter-induced Epstein-Barr virus activation.Murakami A, Toyota K, Ohura S, Koshimizu K, Ohigashi H*.J Agric Food Chem. 2000 May;48(5):1518-23.PMID: 10820053

 

39) Redox regulation of glutathione S-transferase induction by benzyl isothiocyanate: correlation of enzyme induction with the formation of reactive oxygen intermediates.Nakamura Y, Ohigashi H, Masuda S, Murakami A, Morimitsu Y, Kawamoto Y, Osawa T, Imagawa M, Uchida K*.Cancer Res. 2000 Jan 15;60(2):219-25.PMID: 10667562

 

38) In vitro absorption and metabolism of a citrus chemopreventive agent, auraptene, and its modifying effects on xenobiotic enzyme activities in mouse livers.Murakami A, Wada K, Ueda N, Sasaki K, Haga M, Kuki W, Takahashi Y, Yonei H, Koshimizu K, Ohigashi H*.Nutr Cancer. 2000;36(2):191-9.PMID: 10890030

 

37) 1,1-Dimethylallylcoumarins potently suppress both lipopolysaccharide- and interferon-gamma-induced nitric oxide generation in mouse macrophage RAW 264.7 cells.Murakami A, Gao G, Omura M, Yano M, Ito C, Furukawa H, Takahashi D, Koshimizu K, Ohigashi H*.Bioorg Med Chem Lett. 2000 Jan 3;10(1):59-62.PMID: 10636244

 

36) Modifying effects of carotenoids on superoxide and nitric oxide generation from stimulated leukocytes.Murakami A, Nakashima M, Koshiba T, Maoka T, Nishino H, Yano M, Sumida T, Kim OK, Koshimizu K, Ohigashi H*.Cancer Lett. 2000 Feb 28;149(1-2):115-23.PMID: 10737715

 

35) Screening for the in vitro anti-tumor-promoting activities of edible plants from Malaysia.Murakami A, Ali AM, Mat-Salleh K, Koshimizu K, Ohigashi H*.Biosci Biotechnol Biochem. 2000 Jan;64(1):9-16.PMID: 10705442

 

34) Identification of zerumbone in Zingiber zerumbet Smith as a potent inhibitor of 12-O-tetradecanoylphorbol-13-acetate-induced Epstein-Barr virus activation.Murakami A, Takahashi M, Jiwajinda S, Koshimizu K, Ohigashi H*.Biosci Biotechnol Biochem. 1999 Oct;63(10):1811-2.PMID: 10586508

 

33) Immunomodulatory action of citrus auraptene on macrophage functions and cytokine production of lymphocytes in female BALB/c mice.Tanaka T, Sugiura H, Inaba R, Nishikawa A, Murakami A, Koshimizu K, Ohigashi H*.Carcinogenesis. 1999 Aug;20(8):1471-6.PMID: 10426794

 

32) A diacetylenic spiroketal enol ether epoxide, AL-1, from Artemisia lactiflora inhibits 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion possibly by suppression of oxidative stress.Nakamura Y, Kawamoto N, Ohto Y, Torikai K, Murakami A, Ohigashi H*.Cancer Lett. 1999 Jun 1;140(1-2):37-45.PMID: 10403539

 

31) Identification of coumarins from lemon fruit (Citrus limon) as inhibitors of in vitro tumor promotion and superoxide and nitric oxide generation.Miyake Y, Murakami A, Sugiyama Y, Isobe M, Koshimizu K, Ohigashi H*.J Agric Food Chem. 1999 Aug;47(8):3151-7.PMID: 10552623

 

30) Identification of coumarins from the fruit of Citrus hystrix DC as inhibitors of nitric oxide generation in mouse macrophage RAW 264.7 cells.Murakami A, Gao G, Kim OK, Omura M, Yano M, Ito C, Furukawa H, Jiwajinda S, Koshimizu K, Ohigashi H*.J Agric Food Chem. 1999 Jan;47(1):333-9.PMID: 10563895

 

29) Isolation and identification of acetylenic spiroketal enol ethers from Artemisia lactiflora as inhibitors of superoxide generation induced by a tumor promoter in differentiated HL-60 cells. Nakamura Y, Ohto Y, Murakami A, Jiwajinda S, Ohigashi H*. J. Agric. Food Chem. 1998, 46, 5031-5036 

 

28) Superoxide scavenging activity of rosmarinic acid from Perilla frutescens Britton var. acuta f. viridis. Nakamura Y, Ohto Y, Murakami A, Ohigashi H*. J. Agric. Food Chem. 1998, 46, 4545-4550  

 

27) Suppression of tumor promoter-induced oxidative stress and inflammatory responses in mouse skin by a superoxide generation inhibitor 1'-acetoxychavicol acetate.Nakamura Y, Murakami A, Ohto Y, Torikai K, Tanaka T, Ohigashi H*.Cancer Res. 1998 Nov 1;58(21):4832-9.PMID: 9809987

 

26) Prevention by 1'-acetoxychavicol acetate of the induction but not growth of putative preneoplastic, glutathione S-transferase placental form-positive, focal lesions in the livers of rats fed a choline-deficient, L-amino acid-defined diet.Kobayashi Y, Nakae D, Akai H, Kishida H, Okajima E, Kitayama W, Denda A, Tsujiuchi T, Murakami A, Koshimizu K, Ohigashi H, Konishi Y*.Carcinogenesis. 1998 Oct;19(10):1809-14.PMID: 9806163

 

25) Citrus auraptene exerts dose-dependent chemopreventive activity in rat large bowel tumorigenesis: the inhibition correlates with suppression of cell proliferation and lipid peroxidation and with induction of phase II drug-metabolizing enzymes.Tanaka T, Kawabata K, Kakumoto M, Hara A,Murakami A, Kuki W, Takahashi Y, Yonei H, Maeda M, Ota T, Odashima S, Yamane T, Koshimizu K, Ohigashi H*.Cancer Res. 1998 Jun 15;58(12):2550-6.PMID: 9635577

 

24) Inhibition by 1'-acetoxychavicol acetate of lipopolysaccharide- and interferon-gamma-induced nitric oxide production through suppression of inducible nitric oxide synthase gene expression in RAW264 cells.Ohata T, Fukuda K, Murakami A, Ohigashi H, Sugimura T, Wakabayashi K*.Carcinogenesis. 1998 Jun;19(6):1007-12.PMID: 9667738

 

23) Inhibitory effects of curcumin and tetrahydrocurcuminoids on the tumor promoter-induced reactive oxygen species generation in leukocytes in vitro and in vivo.Nakamura Y, Ohto Y, Murakami A, Osawa T, Ohigashi H*.Jpn J Cancer Res. 1998 Apr;89(4):361-70.PMID: 9617340

 

22) Screening of edible Japanese plants for nitric oxide generation inhibitory activities in RAW 264.7 cells.Kim OK, Murakami A, Nakamura Y, Ohigashi H*.Cancer Lett. 1998 Mar 13;125(1-2):199-207.PMID: 9566716

 

21) Niaziminin, a thiocarbamate from the leaves of Moringa oleifera, holds a strict structural requirement for inhibition of tumor-promoter-induced Epstein-Barr virus activation.Murakami A, Kitazono Y, Jiwajinda S, Koshimizu K, Ohigashi H*.Planta Med. 1998 May;64(4):319-23.PMID: 9619112

 

20) Screening for in vitro anti-tumor-promoting activities of edible plants from Indonesia.Murakami A, Morita H, Safitri R, Ramlan A, Koshimizu K, Ohigashi H*.Cancer Detect Prev. 1998;22(6):516-25.PMID: 9824374

 

19) Chemoprevention of 4-nitroquinoline 1-oxide-induced oral carcinogenesis by citrus auraptene in rats.Tanaka T, Kawabata K, Kakumoto M, Matsunaga K, Mori H, Murakami A, Kuki W, Takahashi Y, Yonei H, Satoh K, Hara A, Maeda M, Ota T, Odashima S, Koshimizu K, Ohigashi H*.Carcinogenesis. 1998 Mar;19(3):425-31.PMID: 9525276

 

18) Citrus auraptene inhibits chemically induced colonic aberrant crypt foci in male F344 rats.Tanaka T, Kawabata K, Kakumoto M, Makita H, Hara A, Mori H, Satoh K, Hara A, Murakami A, Kuki W, Takahashi Y, Yonei H, Koshimizu K, Ohigashi H*.Carcinogenesis. 1997 Nov;18(11):2155-61.PMID: 9395216

 

17) Chemoprevention of azoxymethane-induced rat colon carcinogenesis by a xanthine oxidase inhibitor, 1'-acetoxychavicol acetate.Tanaka T, Kawabata K, Kakumoto M, Makita H, Matsunaga K, Mori H, Satoh K, Hara A, Murakami A, Koshimizu K, Ohigashi H*.Jpn J Cancer Res. 1997 Sep;88(9):821-30.PMID: 9369929

 

16) A xanthine oxidase inhibitor 1'-acetoxychavicol acetate inhibits azoxymethane-induced colonic aberrant crypt foci in rats.Tanaka T, Makita H, Kawamori T, Kawabata K, Mori H, Murakami A, Satoh K, Hara A, Ohigashi H, Koshimizu K*.Carcinogenesis. 1997 May;18(5):1113-8.PMID: 9163704

 

15) Auraptene, a citrus coumarin, inhibits 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion in ICR mouse skin, possibly through suppression of superoxide generation in leukocytes.Murakami A, Kuki W, Takahashi Y, Yonei H, Nakamura Y, Ohto Y, Ohigashi H, Koshimizu K*.Jpn J Cancer Res. 1997 May;88(5):443-52.PMID: 9247600

 

14) 1'-Acetoxychavicol acetate, a superoxide anion generation inhibitor, potently inhibits tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in ICR mouse skin.Murakami A, Ohura S, Nakamura Y, Koshimizu K, Ohigashi H*.Oncology. 1996 Sep-Oct;53(5):386-91.PMID: 8784473

 

13)  Inhibitory effect of pheophorbide a, a chlorophyll-related compound, on skin tumor promotion in ICR mouse.Nakamura Y, Murakami A, Koshimizu K, Ohigashi H*.Cancer Lett. 1996 Nov 29;108(2):247-55.PMID: 8973602

 

12) Identification of pheophorbide a and its related compounds as possible anti-tumor promoters in the leaves of Neptunia oleracea. Nakamura Y, Murakami A, Koshimizu K, Ohigashi H*. Biosci Biotechnol Biochem. 1996 Jun;60(6):1028-30. PMID: 8695903

 

11) Chemopreventive effect of a xanthine oxidase inhibitor, 1'-acetoxychavicol acetate, on rat oral carcinogenesis.Ohnishi M, Tanaka T, Makita H, Kawamori T, Mori H, Satoh K, Hara A, Murakami A, Ohigashi H, Koshimizu K*.Jpn J Cancer Res. 1996 Apr;87(4):349-56.PMID: 8641965

 

10) Glyceroglycolipids from Citrus hystrix, a traditional herb in Thailand, potently inhibit the tumor promoting activity of 12-O-tetradecanoylphorbol 13-acetate in mouse skin. Murakami A, Nakamura Y, Koshimizu K, Ohigashi H*.  J. Agric. Food Chem. 1995, 43, 2779-2783 

 

9) Screening for in vitro anti-tumor promoting activities of edible plants from Thailand. Murakami A, Jiwajinda S, Koshimizu K, Ohigashi H*.Cancer Lett. 1995 Aug 16;95(1-2):139-46.PMID: 7656222

 

8) Screening of tissue cultures and thalli of lichens and some of their active constituents for inhibition of tumor promoter-induced Epstein-Barr virus activation.Yamamoto Y, Miura Y, Kinoshita Y, Higuchi M, Yamada Y, Murakami A, Ohigashi H, Koshimizu K*. Chem Pharm Bull (Tokyo). 1995 Aug;43(8):1388-90. PMID: 7553984

 

7) Possible anti-tumor promoting properties of edible plants from Thailand, and identification of an active constituent, cardamonin, of Boesenbergia pandurata. Murakami A, Kondo A, Nakamura Y, Ohigashi H, Koshimizu K*. Biosci. Biotechnol. Biochem 1993, 57, 1971-1973  

 

6) 1'-Acetoxychavicol acetate as a potent inhibitor of tumor promoter-induced Epstein-Barr virus activation from Languas galanga, a traditional Thai condiment. Kondo A, Ohigashi H, Murakami A, Suratwadee J, Koshimizu K*. Biosci. Bietechnol. Biochem 1993, 57, 1344-1345  

 

5) Bitter cyanoglucosides from Lophira alata. Murakami A, Ohigashi H, Tanaka S, Hirota M, Irie R, Takeda N, Tatematsu A, Koshimizu K*.  Phytochemistry 1993, 32, 1461-1466

  

4) Possible anti-tumor promoters: Bi- and tetraflavonoids from Lophira alata. Murakami A, Tanaka S, Ohigashi H, Hirota M, Irie R, Takeda N, Tatematsu A, Koshimizu K*. Phytochemistry. 1992. 31, 2689-2693 

 

3) Chalcone tetramers, lophirachalcone and alatachalcone, from Lophira alata as possible anti-tumor promoters. Murakami A, Tanaka S, Ohigashi H, Hirota M, Irie R, Takeda N, Tatematsu A, Koshimizu K*.Biosci Biotechnol Biochem. 1992 May;56(5):769-72. PMID: 1369383 

 

2) Inhibitory effects of new types of biflavonoid-related polyphenols; lophirone A and lophiraic acid, on some tumor promoter-induced biological responses in vitro and in vivo. Murakami A, Ohigashi H, Jisaka M, Hirota M, Irie R, Koshimizu K*.Cancer Lett. 1991 Jun 14;58(1-2):101-6. PMID: 1904796

 

1) Possible inhibitor of tumor promotion and related polyphenol from Lophira alata, a medicinal plant in tropical west Africa. Murakami A, Ohigashi H, Nozaki H, Tada T, Kaji M, Koshimizu K*. Agric. Biol. Chem. 1991, 55, 1151-1153

 

 

Reviews

 

23)Impact of hormesis to deepen our understanding of the mechanisms underlying the bioactivities of polyphenols, Murakami A*, Curr Opin Biotechnol,2023, in press. 

 

22) Novel mechanisms underlying bioactivities of polyphenols via hormesis, Murakami A*, Curr Opin Toxicol,2022,30,100337. doi.org/10.1016/j.cotox.2022.02.010

 

21) Hormesis-mediated mechanisms underlying bioactivities of phytochemicals. Murakami A*, Curr Pharmacol Rep.2020,6,325-334. doi.org/10.1007/s40495-020-00235-4

 

20) Non-specific protein modifications may be novel mechanism underlying bioactive phytochemicals. Murakami A*. J Clin Biochem Nutr.,2018, 62 (2):115-123: doi: 10.3164/jcbn.17-113.

 

19) Dose-dependent functionality and toxicity of green tea polyphenols in experimental rodents. Murakami A*, Arch Biochem Biophys, 2014;557:3-10. doi: 10.1016/j.abb.2014.04.018.

 

18) Modulation of protein quality control systems as novel mechanisms underlying functionality of food phytochemicals. Ohnishi K, Irie K, Murakami A*, Funct Food Health Disease, 2013;3(10):400-15.

 

17) Modulation of protein quality control systems by food phytochemicals. Murakami A*, J Clin Biochem Nutr, 2013;52(3):215-27. PMID: 23704811

 

16) Target molecules of food phytochemicals: Food science bound for the next dimension. Murakami A*, Ohnishi K. Food Funct., 2012 May;3(5):462-76. PMID: 22377900

 

15) Mechanisms underlying food functionality via molecular chaperones: Chemical training hypothesis.Murakami A*, Ohnishi K. J Food Drug Anal., 2012;20(suppl.1):257-260.

 

14) Dietary flavonoids as cancer-preventive biofactors. Nishiumi S#, Miyamoto S#, Kawabata K#, Ohnishi K, Mukai R, Murakami A, Ashida H, Terao J*. Front Biosci, (Schol Ed). 2011 Jun 1;3:1332-62.PMID:21622274. #These authors equally contributed.

 

13) Chemoprevention with phytochemicals targeting inducible nitric oxide synthase. Murakami A*. Forum Nutr. 2009;61:193-203. PMID: 19367123

12) Multitargeted cancer prevention by quercetin.Murakami A, Ashida H, Terao J*.Cancer Lett. 2008 Oct 8;269(2):315-25. Epub 2008 May 7. Review.PMID: 18467024 Three authors equally contributed. 

> 200 citations (as of August 2014)

 

11)  Ursolic acid: an anti- and pro-inflammatory triterpenoid.Ikeda Y, Murakami A, Ohigashi H*.Mol Nutr Food Res. 2008 Jan;52(1):26-42. Review.PMID: 18203131

10) Targeting NOX, INOS and COX-2 in inflammatory cells: chemoprevention using food phytochemicals.Murakami A*, Ohigashi H.Int J Cancer. 2007 Dec 1;121(11):2357-63. Review. PMID: 17893865 

This article was in the top twenty of a total of 9340 published, 807 of which were downloaded online (from Volumes 120-121, 2007). 

9)  Cancer-preventive anti-oxidants that attenuate free radical generation by inflammatory cells.Murakami A*, Ohigashi H.Biol Chem. 2006 Apr;387(4):387-92. Review.PMID: 16606336

 

8)  Cancer prevention with food factors: alone and in combination.Ohigashi H*, Murakami A.Biofactors. 2004;22(1-4):49-55. Review.PMID: 15630251

7)  Search for Naturally-occurring Antioxidative Chemopreventors on the Basis of the Involvement of Leukocyte-derived Reactive Oxygen Species in Carcinogenesis.Nakamura Y, Murakami A, Ohigashi H*.Asian Pac J Cancer Prev. 2000;1(2):115-120.PMID: 12718677 

 

6) Chemoprevention: insights into biological mechanisms and promising food factors. Murakami A, Ohigashi H, Koshimizu K* (1999) , Food Rev. Int., 15, 335-395.

 

5)  An approach to functional food: cancer preventive potential of vegetables and fruits and their active constituents.Ohigashi H, Murakami A, Koshimizu K*.Nutr Rev. 1996 Nov;54(11 Pt 2):S24-8. Review. No abstract available. PMID: 9110571 

4)  Chemoprevention with food phytochemicals: screening, rodent studies, and action mechanisms.Murakami A, Koshimizu K., Ohigashi H*., , J Med Food, 1, 29-38 (1998)

 

3)  Anti-tumor promotion with food phytochemicals: a strategy for cancer chemoprevention.Murakami A, Ohigashi H, Koshimizu K*.Biosci Biotechnol Biochem. 1996 Jan;60(1):1-8. Review.PMID: 8824818 

 

2)  An approach to functional food: cancer preventive potential of vegetables and fruits and their active constituents. Ohigashi H, Murakami A, Koshimizu K*.Nutr Rev. 1996 Nov;54(11 Pt 2):S24-8. Review. No abstract available. PMID: 9110571

1)  A. Murakami, H. Ohigashi, K. Koshimizu*. Possible anti-tumour promoting properties of traditional Thai food items and some of their active constituents., Asia Pacific J Clin Nutr, 3, 185-191 (1994)

 

 

Proceedings and book chapters

 

22) A. Murakami*. Regulation of inflammation-associated intestinal diseases with phytochemicals. In Cancer and Inflammation Mechanisms: Chemical, Biological, and Clinical Aspects. Y Hiraku, S Kawanishi, H Ohshima (Eds), pp.355-369, John Wiley & Sons (2014).

 

21) A. Murakami*. Anti-inflamamtory and chemopreventive potentials of citrus auraptene. In Clinical Aspects of Functional Foods and Nutraceuticals. D. Ghosh, D. Bagchi, T Konishi (Eds.), pp.93-103, CRC Press (2014). 

 

20) A. Murakami*. Modyfing effects of polyphenols on acute colitis and inflammation-associated colon carcinogenesis. In Polyphenols in Human Health and Disease. RR. Watson, VR Preedy, S Zibadi (Eds), pp.1231-1240, Academic Press (2014).

 

19) A. Murakami*. Potential Toxicity of Green Tea Polyphenols in Colitis. In Tea in Health and Disease Prevention. V.R.Preedy (Ed), pp. 1503-1516, Academic Press (2012).

 

18) A. Murakami*. Chemoprevention with Phytochemicals Targeting Inflammation-associated Enzymes. In Phytochemicals and Human Health, A. A. Farooqui and T. Farooqui (Eds), pp. 99-134, Nova Science Publishers, Inc. (2011).

 

17) A. Murakami*. Cancer Preventive Phytochmicals from Southeast Asian Countries: In Vivo Activities and Underlying Molecular Mechanisms. In Bioactive Foods and Extracts, RR Watson, VR Preedy (Eds), pp. 211-221, CRC Press (2010).

 

16) A. Murakami and H. Ohigashi*. Anti-inflammatory and Anti-carcinogenesis Potentials of Citrus Coumarins and Polymethoxyflavonoids. In Nutrigenomics and Proteomics in Health and Disease, Y. Mine, K. Miyashita and F. Shahidi (Eds), pp. 311-324, Wiley-Blackwell (2009).

 

15) A. Murakami*. Chemoprevention with Food Phytochemicals Targeting Inducible Nitric Oxide Synthase., In Food Factors for Health Promotion, T. Yoshikawa (Ed.) , pp.193-203, Karger, Basel, Switzerland (2009).

 

14) A. Murakami*, Y. Ikeda, and H. Ohigashi, Modulation of MAPK pathways by food phytochemicals: Risks and Benefits., In Dietary Modulation of Cell Signaling Pathways, (eds.), Y-J Surh, Z. Dong, E. Cadenas, and L. Packer., pp.75-90., Taylor and Francis Group, LLC, New York (2009).

 

13) A. Murakami, H. Ohigashi*. Cancer preventive agents in zingiberaceous plants from Southeast Asian countries. In. Cancer: Disease Progression and Chemoprevention, Takuji Tanaka (Ed.), Research Singpost, Kerala, India, pp.217-238 (2007)

12) A. Nishikawa, H. Nakamura, I-S. Lee, F. Furukawa, A. Murakami, H. Ohigashi, T. Umemura, M. Hirose*. Chemoprevention effects of 1'-acetoxychavicol acetate and auraptene on stomach carcinogenesis in rats initiated with N-methyl-N'-nitro-N-nitrosogaunidine. In. Cancer: Disease Progression and Chemoprevention, Takuji Tanaka (Ed.), Research Singpost, Kerala, India, pp. 267-276 (2007)

11) S. Miyamaoto, Y. Yasui, A. Murakami, T. Tanaka*. Molecular mechanism of colorectal cancer. In. Cancer: Disease Progression and Chemoprevention, Takuji Tanaka (Ed.), Research Singpost, Kerala, India, pp. 45-56  (2007)

10) A. Murakami*, H. Ohigashi, Molecular targets for anti-inflammation and dietary component-drug synergy, In. Food Drug Synergy and Safety, Lilian U. Thompson and Wendy E. Ward (Eds.), CRC Press., pp.287-317 (2006)

9) A. Murakami*, H. Ohigashi, Polymethylated flavonoids: Cancer preventive and therapeutic potentials derived from anti-inflammatory and drug metabolism-modifying properties. In. Phytochemicals in Health and Disease, In. Y. Bao and R. Fenwick (Eds.), Mercel Dekker, pp.187-211 (2004)

8) A. Murakami, Y. Nakamura, K., H. Ohigashi*. Suppressive effects of 1'-acetoxychavicol acetate on superoxide and nitric oxide in cell culture systems, and on hydrogen peroxide in mouse skin. Free Radicals in Food, Chemistry, Nutrition, and Health Effects, ACS Symposium Series 807, American Chemical Society, Washington D.C., pp. 329-341 (2002)

7) M. A. Huffman*, H. Ohigashi, M. Kawanaka, J. E. Page, G. C. Kirby, M. Gasquet, A. Murakami, and K. Koshimizu, African great ape self-medication: a new paradigm for treating parasite disease with natural medicines ? In. Towards Natural Medicine Research in the 21st century H. Ageta, N. Aimi, Y. Ebizuka, T. Fujita, and G. Honda (Eds.), Elsevier Science B. V., pp.113-123 (1998)

6) K. Koshimizu, A. Murakami, H. Ohigashi*, Cancer preventive potentials of vegetables and fruits from southeast Asia and some of their active constituents, Third International Symposium on Diversification of Vegetable Crops, pp.45-54 (1998)

5) A. Murakami, W. Kuki, Y. Takahashi, H. Yonei, T. Tanaka, H. Makita, K. Wada, N. Ueda, M. Haga, Y. Nakamura, Y. Ohto, O.-K. Kim, H. Ohigashi, K. Koshimizu*, Auraptene, an alkyloxylated coumarin from Citrus natsudaidai HAYATA, inhibits mouse skin tumor promotion and rat colonic aberrant crypt foci formation. In. ACS Symposium Series 702 "Functional Foods for Disease Prevention I", American Chemical Society, Washington D.C., pp. 86-95 (1998)

4) A. Murakami, Y. Nakamura, Y. Ohto, T. Tanaka, H. Makita, K. Koshimizu, H. Ohigashi*, Cancer preventive phytochemicals from tropical Zingiberaceae. In Food for Health in the Pacific Rim (3rd International Food Science and Technology), Food & Nutrition Press, Inc., Conneticut, pp.125-133 (1998)

3) H. Ohigashi, A. Murakami, Y. Nakamura, K. Koshimizu*, Anti-tumor promoters from edible Thai plants: isolation, cancer preventive potential, and action mechanisms. In. Food Factors for Cancer Prevention, H. Ohigashi, T. Osawa, J. Terao, S. Watanabe, T. Yoshikawa (Eds.), Springer-Verlag, Tokyo, pp.188-193 (1997)

2) T. Tanaka, H. Makita, M. Ohnishi, A. Murakami, K. Koshimizu, Y. Nakamura, H. Ohigashi, K. Koshimizu*, Chemoprevention of oral and colon carcinogenesis by natural compounds protocatechuic acid, 1'-acetoxychavicol acetate, S-methyl methane thiosulfonate, and hesperidin from vegetables and fruits. In. Food Factors for Cancer Prevention, H. Ohigashi, T. Osawa, J. Terao, S. Watanabe, T. Yoshikawa (Eds.), Springer-Verlag, Tokyo, pp.194-199 (1997)

1) H. Ohigashi, A. Murakami, K. Koshimizu*, Antitumor promoters from edible plants. In.  Food Phytopchemicals for Cancer Prevention II, Teas, Spices, and Herbs. C.-T.Ho, T. Osawa, M.-T. Huang, R.T. Rosen (Eds.), ACS Symposium Series 547, American Chemical Society, Washington D.C., pp.251-261 (1994)

 

Invited international symposia

 

38)A. Murakami, Novel mechanisms underlying bioactivities of phytochemicals, The 5th International Symposium on 'Convergence of Bio-Health and Food Science, Don-A University, Busan, Korea, Mar. 15th, 2019.

 

37)A. Murakami, Phytochemicals may exhibit bioactivities via hormesis: roles of proteo-stress and adaptation, The 9th International Conference on Nutrition and Physical Activity (NAPA2018), Taichung, Taiwan, Dec. 17th, 2018.

 

36) A. Murakami, Stress-mediated mechanisms underlying bioactivities of phytochemicals, The 256th Annual Meeting of the American Chemical Society, Boston, USA, 2018.

 

35) A. Murakami, Non-specific interactions of zerumbone with biological proteins may be associated with its anti-inflammatory functions., The 29th Annual and International Meeting of the Japanese Association for Animal Cell Research (JAACT2016), Kobe, Japan, Nov.9-12.

 

34) A. Murakami, Anti-inflammatory and chemopreventive activities of phytochemicals from Southeast Asian countries, Food for Health International Conference 2016, Kagoshima, Japan, March 21-23. (plenary lecture)

 

33)A. Murakami, Curcumin may exhibit physiological functions via proteo-stress, International Conference on Food Factors, Seoul, South Korea, Nov.22-25, 2015.

 

32) A Murakami, Roles of non-specific interactions of phytochemials with biological proteins in their bioactivities, International Conference and Exhibition on Nutraceuticals and Functional Foods 2013, Taipei, Taiwan, Nov.5-9.

 

31) A Murakami, Low and medium but not high doses of green tea polyphenols ameliorate dextran sodium sulfate-induced hepatic and kidney dysfunctions, Antioxidants and Redox Process in Health 2013, Sao Paulo, Brazil, October 21-22, 2013.

 

30) A Murakami and K Ohnishi, Activation of Protein Quality Control Systems by Food Phytochemicals: Chemical Training Hypothesis. 13th International Conference of FFC - First International Symposium of ASFFBC: Functional and Medical Foods with Bioactive Compounds: Science and Practical Application, Kyoto, Japan, May 11-12, 2013, 

29) A. Murakami, Effects of phytochemicals on protein quality control systems, International Conference and Exhibition on Nutraceuticals and Functional Foods 2012, Kona, U.S.A., Dec.1-6.

 

28) A. Murakami, Suppressive effects of anthocyanin-rich tea "Sunrouge" on dextran sodium sulfate-induced colitis in female ICR mice, 2012 Annual Meeting of Korean Society of Food Science and Technology, Daejeon, South Korea, June 13-15.

 

27) A. Murakami, Roles of non-specific bindings of phytochemicals in their bioactivities, Emergence of Personalized Health Care System Based on Food-Medicine, Seoul, South Korea, June 13. 

 

26) A. Murakami. Effects of chemopreventive phytochemicals on induction of molecular chaperones, International Symposium on Frontiers in Cancer Research 'Bioactive Natural Products for Cancer Prevention`, Seoul, South Korea, Nov. 25th, 2011.

 

25) A. Murakami and K. Ohnishi. Mechanisms underlying food functionality via molecular chaperones: Chemical training hypothesis, The 5th International Conference on Food Factors, Taipei, Taiwan, Nov.20-23, 2011.

 

24) A. Murakami and K. Ohnishi. Molecular chaperones as the novel target of phytochemicals, 2011 Annual Meeting of International for Neutraceuticals & Functional Foods, Sapporo, Japan, Nov.14-17, 2011.

 

23) A. Murakami, K. Ohnishi. Non-specific binding of phytochemicals to biological proteins may play significant role in their physiological functions: 'Chemical training' hypothesis., the 40th Annual Meeting of the Korean Society of Food and Nutrition, Busan, Korea, Nov.1-2, 2011.

 

22) A. Murakami, S. Miyamoto. Preventive effects of flavonoids on hyperleptinemia and colitis-related colon carcinogenesis in ICR mice. The 4th International Gastrointestinal Consensus Symposium (IGICS), Kyoto, Feb.18-19, 2011.

21) A. Murakami, M. Yasuda, N.H. Colburn, K. Irie. Genistein Suppresses Lipopolysaccharide-induced Down-regulation of Programmed Cell Death 4 in RAW 264.7 Mouse Macrophages, Pacifichem (Honolulu, HI), Dec. 15-20, 2010.

 

20) A. Murakami and K. Ohnishi, Possible Target Molecules of Zerumbone, a Chemopreventive Agent from Zingiber zerumbet Smith., 3rd International Symposium on Translational Cancer Research: Cell Signaling and Cancer Therapy (Bhubaneshwar, India), Dec.18-21, 2009

 

19) A. Murakami, Food phytochemicals from plants native to subtropical countries: impact on cancer prevention and underlying molecular mechanisms., 2nd International Symposium on Translational Cancer Research: Natural Products and Cancer (Mumbai, India), Dec. 9-12, 2007

18) A. Murakami, H. Ohigashi, Versatile effects of citrus polymethoxyflavonoids on inflammatory cells., 3rd International Conference on Polyphenols and Health (Kyoto, Japan), Nov. 25-28, 2007.

17) A. Murakami, H. Ohigashi, Benefits and risks of functional food factors., Korea-China-Japan Food Science Symposium (Jeju, Korea), June 15th, 2006.

16) A. Murakami, H. Ohigashi, Food phytochemicals as xenobiotics: friend or foe ?., The 1st Asia Pacific International Society for the Study of Xenobiotics Meeting (APISSX), (Jeju, Korea) May 24-27, 2006.

15) A. Murakami, T. Nishizawa, T. Shigemori, H. Ohigashi, Suppression of cycooxygenase-2 expression with food phytochemicals: efficacy for cancer prevention and underlying molecular mechanisms., Pacifichem 2005 (Honolulu, HI). Dec. 15-20, 2005.

14) A. Murakami, H. Ohigashi. Cancer preventive anti-oxidants that attenuate free radical generation from inflammatory cells., Chronic Oxidative Stress and Cancer (Hidelberg, Germany) Oct. 23-26, 2005.

13) A. Murakami, K.H. Kwon, H. Ohigashi. Suppressive effects of dietary rutin and quercetin on dextran sulfate sodium-induced colitis: implications for colon cancer prevention., WorlNutra2004 (San Francisco, CA) Nov. 7-11, 2004.　

12) A. Murakami, M.H. Kim, K. Kawabata, H. Ohigashi. Green tea catechins enhance matrix metalloproteinase-7 induction in human colorectal adenocarcinoma cell lines., The 2nd Asia Pacific Organization for Cancer Prevention General Assembly Conference. (Seoul, Korea) Nov. 1-3, 2004.

11) A. Murakami, H. Ohigashi. Combination of anti-oxidants: a strategy for chemoprevention., 'Dietary Factors and Cancer Prevention: Current Premises and Future Promises'. (Rochester, MN) Sep.23-25, 2004.　　　

10) A. Murakami. Attenuation of infection-induced chronic inflammation: a practical and promising means for cancer prevention., 3rd International Conference on Food Factors. (Tokyo, Japan) Dec. 5-8, 2003.

9) A. Murakami. Suppression of free radical generating pathways by food factors., 'Free Radicals in Health and Disease', SRFF-Asia (Seoul, Korea) Nov. 6-8, 2003.

8) A. Murakami, H. Ohigashi. Cancer preventive potentials of edible plants from Southeast Asian countries., International Phytochemicals Symposium 'The Beneficial Effects of Phytochemicals in Human Health' (Seoul, Korea) Oct. 17, 2003.

7) A. Murakami, H.W. Kim, H. Ohigashi. Suppression of free radical-induced mutation of animal cell genes by food factors., The 15th Annual and International Meeting of Japanese Association for Animal Cell technology (Tokyo, Japan) Nov. 11-15, 2002.

6) A. Murakami, H. Ohigashi. Chemopreventive food phytochemicals: screening, action mechanisms, and metabolism., International Symposium on Dietary and Medicinal Antimutagens and Anticaicinogens: Molecular Mechanisms and Chemopreventive Potential. (Seoul, Korea) Oct. 17-19, 2001.

5) A. Murakami, H. Ohigashi. A citrus polymethoxyflavone, nobiletin: its anti-inflammatory and chemopreventive potentials and bioavailability., 221st American Chemical Society National Meeting (San Diego, CA), Apr. 1-4, 2001.

4) A. Murakami, H. Ohigashi. Inhibitory effects of auraptene on phorbol ester- and endotoxin-induced inflammatory and oxidative responses., Pacifichem（Honolulu, HI）, Dec. 14-19, 2000.

3) A. Murakami, H. Ohigashi. Search for chemopreventive agents on the basis of the involvement of oxidative stress and inflammation in carcinogenesis., The 13th annual Meeting of the Japanese Association for Animal Cell Technology (JAACT 2000) (Fukuoka, Japan) Nov. 17-21, 2000.

2) A. Murakami, H. Ohigashi. Food phytochemicals suppressing free radical generation: implications for cancer chemoprevention., 219th American Chemical Society National Meeting (San Francisco, CA), Mar. 26-30, 2000.

 

1) A. Murakami, H. Ohigashi. Citrus nobiletin suppresses phorbol-ester-induced skin inflammation, oxidative stress, and tumor-promotion in mice., 2nd International Conference on Food Factors (Kyoto, Japan), Dec. 12-17, 199～～

 

■海外研究室でのセミナーなど

※7)はマウス耳殻炎症試験のデモンストレーションとセミナーを、他はセミナーを行った。

 

1) Korea Food Research Institute, South Korea

(Host: Dr. Suk Hoo Yoon, October 2003)

2) College of Pharmacy, Seoul National University, South Korea

(Host: Dr. Young Joon Surh, October 2003)

3)  College of Natural Resources, University of California, USA

(Host: Dr. Isao Kubo, March 2000)

4)  Immunology and Medical Genetics, The Ohio State University, USA

(Host: Dr. Marshall V. Williams, March 1999)

5)  Institute of Bioscience, University Putra Malaysia, Malaysia

（Host: Dr. Adbul Manaf Ali, September 1997）

6)  Institute of Bioscience, University Putra Malaysia, Malaysia

（Host: Dr. Adbul Manaf Ali, November 1996）

7)   Faculty of Pharmacy, Padjadjaran University, Indonesia

（Host: Dr. Anas Subarnas, March 1996）

 

国内招待講演

 

63)村上　明、日本の食品機能学における研究成果を振り返り、未来を見つめる、日本農芸化学会2024年度大会シンポジウム（2024年3月26日、東京）

 

62)石坂朱里、藤原なお、向井理恵、西川美宇、生城真一、村上　明、授乳期のフラボノイド摂取が乳児に与える影響、日本農芸化学会2024年度大会シンポジウム（2024年3月26日、東京）

 

61)村上　明、ホルミシスの概念から見えてくるポリフェノールの新しい作用機構、第28回チョコレート・ココア国際栄養シンポジウム（2024年2月9日、東京）

 

60)村上　明、食と健康の諸問題　～ウソ、ホント、不明～、第3回食と健康の井戸端会議（2024年1月9日、姫路市）

 

59)村上　明、心身の健康も秘訣は適度なストレス　～野菜の研究からわかったこと～、姫路市オープンカレッジ（2023年9月25日、姫路市）

 

58)村上　明、食べものをなぜ食べるか？、キャリアサポーターに話を聞く会、兵庫県立兵庫高等学校（2023年7月7日、神戸市）

 

57)村上　明、食と健康　～この楽しくて難しい世界を見つめる～、第2回食と健康の井戸端会議（2023年6月11日、門真市）

 

56)村上　明、野菜や果物に含まれる異物「ファイトケミカル」が持つ健康効果の謎、中部大学講演会（2022年12月22日、愛知）

 

55)村上　明、作用機構研究者の立場から見つめる食品機能学のミライ、食のミライ技術フェア2022（2022年9月30日、東京）

 

54)村上　明、ホルミシスの視点から考える機能性食品成分の新しい作用機構、レドックスR&D戦略委員会第3回シンポジウム（2022年9月27日、オンライン）

 

53)村上　明、食品に含まれる健康成分の謎を解く、第1回食と健康の井戸端会議（2022年9月22日、大阪）

 

52)村上　明、ファイトケミカルってどんな物質、医療工学基礎セミナー、先端医療工学研究所（2022年9月13日、姫路市）

 

51)村上　明、食べものをなぜ食べるか？、キャリアサポーターに話を聞く会、兵庫県立兵庫高等学校（2022年7月8日、神戸市）

 

50)Akira Murakami, Novel mechanisms underlying bioactivities of polyphenols via hormesis, 日本農芸化学会2022年度大会シンポジウム（22年3月17日、京都市）

 

49)村上　明、食品機能学の紹介　～食べ物と健康の科学～、兵庫県立長田高等学校「総合的な探求の時間」講演会（22年3月9日、神戸市）

 

48)村上　明、食品機能学　～発展途上の科学～、兵庫県立長田高等学校「総合的な探求の時間」講演会（21年3月5日、神戸市）

 

47)村上　明、ホルミシスを介した機能性食品成分の新しい作用メカニズム、宮崎大学大学院農学工学総合研究科農工定期セミナー「食の科学ユニット」（20年2月17日、宮崎市）

 

46)村上　明、ポリフェノールは体に悪いから体に良い!?　～健康成分の謎を解く～、健康保険組合連合会兵庫連合会（19年11月18日、神戸市）

 

45)村上　明、ストレス応答の視点で解釈する機能性食品成分の新奇作用機構、日本農芸化学会関西支部産官学連携シンポジウム（19年10月30日、龍野市）特別講演

 

44)村上　明、ストレス応答系を介した機能性食品成分の新しい作用機構（19年10月25日、ロート製薬）

 

43)  村上　明、野菜はなぜカラダにいいの？　～ファイトケミカルを知ってますか～、兵庫県立大学附属中学校出前授業（18年11月5日、赤穂郡・兵庫）

 

42)　村上　明、東南アジア産野菜類は宝の山（しかもほとんど手つかず！）、日本農芸化学中四国支部第35回市民フォーラム（18年10月13日、徳島）

 

41)村上　明、ファイトケミカルの作用機構をホルミシスの概念で理解する、日本食品・機械研究会（17年9月16日、三島）特別講演

 

40)村上　明、亜熱帯産ショウガ科植物成分のユニークな機能性と作用機構、第32回日本香辛料研究会シンポジウム（17年9月1日、加古川）

 

39)村上　明、野菜類の健康効果をケミカルトレーニングの視点から考える、第９回北陸バイオシンポジウム（16年11月4日、福井）

 

38)村上　明、食品機能性から副作用研究への展開　～ネガティブデータを見つめ、拾い、育てる～、第15回健康食品講座（神戸薬科大学エクステンションセンター主催、16年2月28日、神戸）

 

37)村上　明、植物由来機能性成分の新しい作用機構の可能性、第28回日本動物細胞工学会シンポジウム（15年7月9日、仙台）

 

36)村上　明、野菜がなぜ体に良いのか？　～新しい視点で考える～、神戸薬科大学、第12回健康食品講座（15年2月22日、神戸）

 

35)村上　明、天然物化学を端緒とした食品機能学だからこそ、できたこと、南北会（15年2月14日、京都）

 

34)村上　明、生体タンパク質との非特異的相互作用を介した食品成分の機能性発現機構、第７回日本食品免疫学会シンポジウム（14年、6月30日、東京）

 

33)村上　明、プロテオホルミシスを介した食品成分の機能性発現機構、日本薬学会シンポジウム（14年、3月29日、熊本）

 

32)村上　明、食品成分によるタンパク質品質管理機構の制御と生理機能への関与、日本動物細胞工学会シンポジウム（14年、2月10日、東京）

 

31)村上　明、ファイトケミカルは体に厳しいからこそ健康に良い、第47回栄養学若手研究者の集い（13年8月23日、つくば）

 

30)村上　明、ファイトケミカルによるproteo-stressとhormesis、第13回日本抗加齢医学会総会（13年6月30日、横浜）

 

29)村上　明、ファイトケミカルのプロテオホルミシス効果、第2回食品免疫学セミナー、近畿大学生物理工学部（13年3月18日、和歌山）

 

28)村上　明、ファイトケミカルによる生体タンパク質ストレスと健康効果、近畿大学農学部第10回アグリバイオセミナー（12年6月28日、奈良）

 

27) 村上　明、大西康太、適度なケミカルストレスによる生体防御機構の強化、第19回日本がん予防学会（12年6月22-23日、岐阜）

 

26) 村上　明、大西康太、ファイトケミカルによるタンパク質ストレスと適応応答、日本酸化ストレス学会（12年6月7日、徳島）

 

25) 村上 明、大西康太、大倉伸哉、中畑恵利奈、松本晋也、生体タンパク質との相互作用を介したケミカルトレーニング、2012年日本農芸化学会シンポジウム（12年03月25日、京都）

 

24) 村上　明、野菜の成分は敵か味方か？　－体に良い理由（わけ）を考えよう－、第46回日本農芸化学会サイエンスカフェ（12年02月28日、京都）

 

23) 村上　明、ケミカルトレーニングを介した食品成分の生体調節機構、京都大学医学研究科大学院教育コース「生活習慣病・老化・代謝医学」コースセミナー（11年12月13日、京都）

 

22) 村上　明、生体防御能に対する緑茶ポリフェノールの二面性、第８回日本カテキン学会総会（11年9月22日、京都）

 

21) 村上　明、食品機能性研究の新しい切り口、日本豆乳協会・技術部会（11年7月29日、東京）

 

20) 村上　明、ファイトケミカルが体に良い理由（わけ）を考える、第16回IFIA（国際食品素材／添加物展・会議、11年05月18日、東京）

19) 村上 明、大西康太、大倉伸哉、中畑恵利奈、松本晋也、分子シャペロンを介した食品因子の生体調節機構：ケミカルトレーニング仮説、2011年日本農芸化学会シンポジウム（11年03月28日、京都）
※東日本大震災の影響で中止となったが、大会としては成立したものとされている。

 

18) 村上　明、食品因子の機能性と安全性： 諸刃の剣が語ること、日本環境変異原学会 第38回大会（09年11月27日、静岡）

 

17) 村上　明、ラボで発生する予想外なデータの行く末、第43回栄養学若手研究者の集い（08年9月29日、大阪）

 

16) 村上　明、大西康太、機能性と安全性に関与する天然テルペノイドの標的分子、2009年日本農芸化学会シンポジウム（09年03月28日、福岡）

15) 村上　明、食品因子の炎症緩和および生体防御機能解析、レドックス生命科学第１７０委員会第１９回研究会（08年8月1日、静岡） 

 

14) 村上　明、アフィニティーゲルを使ったゼルンボン結合タンパク質の解析、第３回ハナショウガ研究会（08年8月2日、大阪） 

 

13) 村上　明、ハナショウガ成分ゼルンボンの抗炎症および生体防御機構、農芸化学会関西支部例会ミニシンポ（08年7月12日、大阪） 

 

12) 村上　明、疾病制御における抗炎症性食品因子の可能性、日本栄養食糧学会中四国・近畿支部合同大会（07年11月17日、広島）

 

11) 村上　明、私が考える食品機能性研究のおもしろさと醍醐味、第５４回日本食品科学工学会（07年9月7日、福岡）

 

10) 村上　明、亜熱帯産ショウガ科植物成分の発がん予防効果と作用分子機構、第１３回日本がん予防学会（07年7月6日、京都）

 

9) 村上　明、金　美慧、大東　肇、ポリフェノールの潜在的逆作用　─細胞・実験動物・ヒトにおける差異─、日本農芸化学会大会（07年3月26日、京都）

 

8) 村上　明、緑茶カテキンに潜在する副作用、第１０回日本フードファクター学会（05年11月24日、岡山）

 

7) 村上　明、炎症細胞のラジカル産生とその変異原性を抑制する食品成分、第５回日本NO学術集会（05年4月27日、札幌）

 

6) 村上　明、発がん抑制物質の作用機構、日本栄養食糧学会(03年5月20日、福岡）

 

5) 村上　明、食品成分による発がん予防に関する基盤的研究、日本農芸化学会（01年3月24日、京都）

 

4) 村上　明、食品成分による発がん予防の可能性、第４３回日本油化学学会関西支部大会（99年11月17日、大阪）

 

3) 村上　明、中村宜督、小清水弘一、大東　肇、食品成分の生体機能　～抗酸化・抗炎症・抗発がん～、日本動物細胞工学学会（99年6月17日、東京）

 

2) 村上　明、炎症性白血球による酸化ストレスの抑制とがんの化学予防、日本農芸化学会大会（98年4月１日、名古屋）

 

1) 村上　明、食品成分と発がん予防：スクリーニングから作用機構解析まで、日本農芸化学会若手シンポジウム（97年4月2日、箱根）

総説

 

31) 村上　明*、ポリフェノールはなぜ効くか？、日本調理科学会誌、55 (1), 54-56 (2022)

 

30)村上　明*、ファイトケミカルの標的分子と作用機構、食と医療、vol.8, 14-21 (2019)

 

29)村上　明*、ファイトケミカルの作用機構をホルミシスの概念で理解する、日本食品・機械研究会誌、38 (1), 21-30 (2018)

 

28)村上　明*, ファイトケミカルが持つoff-target効果の意義　～機能性と潜在的副作用の観点から～, 化学と生物, 印刷中 (2015)

 

27) 村上　明*、生体タンパク質との非特異的な相互作用を介した食品成分の機能性発現機構、薬学雑誌, 135 (1), 47-55 (2015)

 

26) 大西康太、入江一浩、村上　明、発がん抑制物質ゼルンボンのタンパク質変性に起因した生理作用、バイオサイエンスとインダストリー、71(5), 400-406 (2013)

25) 村上　明*、フードファクターやビタミン類による癌予防研究の現状、アンチ・エイジング医学、メディカルレビュー社、8(2)pp59-63 (2012)

24)  大西康太、入江一浩、村上　明*、ハナショウガ含有テルペノイドzerumboneの発がん抑制機構、ビタミン、86(3)、pp133-141 (2012)

23)  村上　明*：ハナショウガとゼルンボン、aromaterapia、No.108, pp.38-40（2011)

22)　村上　明*：亜熱帯ファイトケミカルによるがん予防、Functional Food, vol.4 (4), pp.352-355 (2011)

21)　村上　明*：ショウガ類の機能性成分、Medical Herb, vol.14, pp22-25 (2010)

20)  宮本真吾、村上　明*、肥満と大腸がんをつなぐ因子：レプチン　～柑橘類フラボノイドの新たな大腸発がん抑制メカニズム？～、vol. 642, pp.34-38、フードリサーチ、食品研究社、2008.

19)  村上　明、大東　肇*：ストレス耐性植物成分の魅力と底力、食品工業、pp22-27 (2004)

18)  村上　明、大東　肇*：食品成分による酸化ストレスの制御とその発がん予防物質としての可能性、科学と工業、78, pp.182-187 (2004)

17)  村上　明、金　河元、Marshall V. Williams、大東　肇*：動物細胞培養系を用いた新規変異原性評価法、日本農薬学会誌、29, pp.262-264 (2004)

16)  村上　明*、大東　肇：緑茶カテキンの２つの顔、日本生物工学会誌, 82, pp.472-488 (2004)

15)  村上　明、大東　肇*：発がん予防食品　― 開発へのハードルとブレークスルー ―、Foods and Food Ingredients Journal of Japan, 208, pp.328-334 (2003)

14)  村上　明、大東　肇：食品によるがんの予防研究　― 困難と魅力 ―、化学工業、53 (2), pp.89-93 (2002)

13)  大東　肇、村上　明：熱帯産ショウガ科植物成分の生理機能特性、FOOD Style 21、5 (7), pp.54-57 (2001)

12)  村上　明*：食品成分による発がん予防に関する基盤的研究、日本農芸化学会誌、75(12), 1283-1290 (2001)

※日本農芸化学会奨励賞受賞内容

11) 村上　明、大東　肇*：カンキツ果汁に特異的なフラボノイド、FOOD Style 21、6 (1), pp.75-77 (2000)

10) 大東　肇、村上　明*：がん予防に期待できる植物性食素材、FOOD Style 21, 4 (8), pp.44-49 (2000)

9) 村上　明*：慢性炎症を結ぶ点と線、化学と生物、学会出版センター、37(4), pp.216-218 (1999)

8) 村上　明、大東　肇*：亜熱帯産野菜類の生理機能―その発がん抑制作用に注目、FOOD Style 21、3 (7), pp.35-39 (1999)

7) 村上　明、大東　肇*：癌予防研究の動向とシンポジウムの概要、FOOD Style 21、3 (2), pp.35-36 (1999)

6) 村上　明、大東　肇*：テルペノイド研究の動向とシンポジウムの概要、FOOD Style 21、23 (2), pp.54-55 (1999)

5) 大東　肇*、中村宜督、村上　明：熱帯アジアの食材の発がん抑制効果と活性成分、FOOD Style 21、2 (7), pp.31-35 (1998)

4) 村上　明、大東　肇*：東南アジア産野菜類に含まれる発がん予防物質、BIO INDUSTORY、15, pp. 34-40 (1998)

3) 村上　明、大東　肇、小清水弘一*：発癌予防効果の調査　～タイ国産の野菜で～、Molecular Medicine, 33, pp. 98-99 (1996)

2) 村上　明、小清水弘一、大東　肇*：グリセロ糖脂質の発がんプロモーション抑制作用、BIO INDUSTORY, 13、pp.28-34 (1996)

1) 大東　肇、村上　明、小清水弘一*：植物性食素材に含まれる発癌抑制物質、栄養-評価と治療、12、pp. 111-116 (1995)

コラム・ニュースレター

 

131) 村上　明：食感と美味しさ、FOOD Style 21、20(5); 71-73 (2016)

 

130) 村上　明：科学情報の受け止め方、FOOD Style 21、20(4); 81-83 (2016)

 

129) 村上　明：清酒造り体験、FOOD Style 21、20(3); 73-75 (2016)

 

128) 村上　明：講義と講演、FOOD Style 21、20(2); 70-71 (2016)

 

127) 村上　明：ICoFF2015@Seoul、FOOD Style 21、20(1); 89-91 (2016)

 

126) 村上　明：臭い食べ物、FOOD Style 21、19(12); 70-71 (2015)

 

126) 村上　明：あり得ないダイエット法、FOOD Style 21、19(11); 81-83 (2015)

 

125) 村上　明：ベトナムの食、FOOD Style 21、19(10); 64-67 (2015)

 

124) 村上　明：東北の食べもの、FOOD Style 21、19(9); 86-87 (2015)

 

123) 村上　明：食と健康に関する最近の話題、FOOD Style 21、19(8); 66-67 (2015)

 

122) 村上　明：学生への頻発メッセージ、FOOD Style 21、19(7); 68-69 (2015)

 

121) 村上　明：ビールもろもろ、FOOD Style 21、19(6); 86-87 (2015)

 

120) 村上　明：運動ホルモンは幻に終わるのか、FOOD Style 21、19(5); 94-95 (2015)

 

119) 村上　明：顧みる、FOOD Style 21、19(4); 1-2 (2015)

 

118) 村上　明：食べるものを腸内細菌に指示される？、FOOD Style 21、19(3); 84-85 (2015)

 

117) 村上　明：年末年始の食、FOOD Style 21、19(2); 76-77 (2015)

 

116) 村上　明：お酒を嗜む、FOOD Style 21、19(1); 94-95 (2015)

 

115) 村上　明：研究テーマの設定、FOOD Style 21、18(12); 116-117 (2014)

 

114) 村上　明：初心いろいろ、FOOD Style 21、18(11); 108-109 (2014)

 

113) 村上　明：情報を正しく流す、正しく理解する、FOOD Style 21、18(10); 114-115 (2014)

 

112) 村上　明：鰻、FOOD Style 21、18(9); 100-101 (2014)

 

111) 村上　明：人工化学物質にまつわる誤解、FOOD Style 21、18(8); 98-99 (2014)

 

110) 村上　明：連載100号に寄せて、FOOD Style 21、18(7); 91-92 (2014)

 

109) 村上　明：二転三転するカロリー制限による長寿効果、FOOD Style 21、18(6); 91-93 (2014)

 

108) 村上　明：春の美味しい食べもの、FOOD Style 21、18(5); 101-103 (2014)

 

107) 村上　明：植物におけるフラボノイドの存在意義、FOOD Style 21、18(4); 88-89 (2014)

106) 村上　明：牡蠣は食材の王様、FOOD Style 21、18(3); 81-83 (2014)

105) 村上　明：科学情報を正しく読み取る、FOOD Style 21、18(2); 95-97 (2014)

104) 村上　明：ファイトケミカルの活性本体、FOOD Style 21、18(1); 99-101 (2014)

103) 村上　明：ブラジルの食や酒、FOOD Style 21、17(12); 97-99 (2013)

102) 村上　明：3,000万円のハンバーガー、FOOD Style 21、17(11); 87-89 (2013)

101) 村上　明：想定外の薬効、FOOD Style 21、17(10); 102-103 (2013)

100) 村上　明：食に関する新しい職業や資格、FOOD Style 21、17(9); 96-97 (2013)

99) 村上　明：中国の食事情、FOOD Style 21、17(8); 90-91 (2013)

98) 村上　明：いつ、食べるか？、FOOD Style 21、17(7); 60-61 (2013)

97) 村上　明：食品成分のプロテオホルミシス効果（その２）、FOOD Style 21、17(6); 88-89 (2013)

96）村上　明：ファイトケミカルの色彩と生理機能、FOOD Style 21、17(5); 44-46 (2013)

95）村上　明：食品成分のプロテオホルミシス効果（その１）、FOOD Style 21、17(5); 104-105 (2013)

94）村上　明：冬の王様・鍋料理、FOOD Style 21、17(4); 108-109 (2013)

93）村上　明：ターメリックのターメロン、FOOD Style 21、17(3); 105-107 (2013)

92）村上　明：予想外のデータが出たらどうする？、FOOD Style 21、17(2); 104-106 (2013)

91) 村上　明：健康に関わるhormesis その２、FOOD Style 21、17(1);106-107 (2013)

90) 村上　明：GMトウモロコシ騒動、FOOD Style 21、16(12); 96-97 (2012)

89) 村上　明：身近で面白い研究、FOOD Style 21、16(11); 100-101 (2012)

88) 村上　明：ピロリ菌の新しい制御法、FOOD Style 21、16(10); 64-65 (2012)

87) 村上　明：研究のメンタル面、FOOD Style 21、16(9); 102-103 (2012)

86) 村上　明：韓国弾丸出張、FOOD Style 21、16(8); 86-87 (2012)

85) 村上　明：食に関することわざ、FOOD Style 21、16(7); 74-75 (2012)

84) 村上　明：気になる研究（その２）、FOOD Style 21、16(6); 80-81 (2012)

83) 村上　明：研究のアウトリーチ活動、FOOD Style 21、16(5); 120-121 (2012)

82) 村上　明：レスベラトロールの実績と可能性、FOOD Style 21、16(4); 89-91 (2012)

81) 村上　明：研究室を選ぶ、FOOD Style 21、16(3); 78-79 (2012)

80) 村上　明：私的回顧台北ICoFF、FOOD Style 21、16(2); 84-85 (2012)

79) 村上　明：健康に関わるhormesis、FOOD Style 21、16(1); 68-70 (2012)

78) 村上　明：植物miRNAが動物で見つかった？、FOOD Style 21、15(12); 90-91 (2011)

77) 村上　明：抗酸化物質は寿命を延ばすか？、FOOD Style 21、15(11); 73-75 (2011)

76) 村上　明：未体験ゾーンの摂取量へ、FOOD Style 21、15(10); 80-81 (2011)

75) 村上　明：ロイヤラクチンの発見、FOOD Style 21、15(9); 80-71 (2011)

74) 村上　明：ガスバイオロジー、FOOD Style 21、15(8); 69-71 (2011)

73) 村上　明：別れと出会い、FOOD Style 21、15(7); 80-81 (2011)

72) 村上　明：植物をいじめて創る機能性食品、FOOD Style 21、15(6); 63-65 (2011)

71) 村上　明：食品添加物の安全性、FOOD Style 21、15(5); 92-93 (2011)

70) 村上　明：ポスドク問題、FOOD Style 21、15(4); 92-93 (2011)

69) 村上　明：食歴が遺伝する？、FOOD Style 21、15(3); 78-79 (2011)

68) 村上　明：日本農芸化学会2011@京都シンポ予告編、FOOD Style 21、15(2); 64-65 (2011)

67) 村上　明：緑茶の副作用研究、FOOD Style 21、15(1); 80-81 (2011)

66) 村上　明：反発しあう研究、日本がん予防研究会ニュースレター, No.67, p.5 (2011)

65) 村上　明：シューカツ、FOOD Style 21、14(12); 66-67 (2010)

64) 村上　明：実験をする（久しぶりに）、FOOD Style 21、14(11); 80-81 (2010) 

63) 村上　明：研究室のセミナー、FOOD Style 21、14(10); 66-67 (2010)

62) 村上　明：サリドマイドの標的分子、FOOD Style 21、14(9); 66-67 (2010)

61）村上　明：GAPDHに垣間見る生物の神秘、FOOD Style 21、14(8); 84-85 (2010)

60) 村上　明：科学情報とツイッター、FOOD Style 21、14(7); 70-71 (2010)

59) 村上　明：不要なものを処分する、FOOD Style 21、14(6); 58-59 (2010)

58) 村上　明：ハダカデバネズミ、FOOD Style 21、14(5); 72-73 (2010)

57) 村上　明：仕事の流儀、FOOD Style 21、14(4); 54-55 (2010)

56) 村上　明：野に放つ、FOOD Style 21、14(3); 60-61 (2010)

55) 村上　明：「事業仕分問題」を契機に、FOOD Style 21，14(2); 55-57 (2010)

54) 村上　明：JSoFF2009@KOBE、FOOD Style 21，14(1); 68-69(2010)

53) 村上　明：亜熱帯産フィトケミカルによるがん予防、日本がん予防研究会ニュースレター, No.61, p. 7 (2009)

52) 関口博太、村上　明、ピロリ菌の感染や定着に対するカンキツ成分の抑制作用、果樹試験研究推進協議会ニュースレター、vol.11, pp.6-9 (2009) 

51) 村上　明：Xenohormesis、FOOD Style 21，13(12); 58-59(2009)

50) 村上　明：グュエン先生へ、FOOD Style 21，13(11); 94-95(2009)

49) 村上　明：好きな食べもの（その１）、FOOD Style 21，13(10); 68-69(2009)

48) 村上　明：料理と実験、FOOD Style 21，13(9); 84-85(2009)

47) 村上　明：アンテナ、FOOD Style 21，13(8); 66-67 (2009)

46) 村上　明：フードケミカルバイオロジー、FOOD Style 21，13(7); 80-81(2009)

45) 村上　明：食べ残し、FOOD Style 21，13(6); 76-77(2009)

44) 村上　明：プロジェクト研究、FOOD Style 21，13(5); 68-69 (2009)

43) 村上　明：体育会系研究者、FOOD Style 21，13(4); 72-72 (2009)

42) 村上　明：講義　－聴く立場と行う立場－、FOOD Style 21，13(3); 90-91 (2009)

41) 村上　明：セミナーバトル、FOOD Style 21，13(2); 64-65 (2009)

40) 村上　明：気になる研究（その１）、FOOD Style 21，13(1); 99-101 (2009)

39) 村上　明、森光康次郎：「健康一年生」の発刊に寄せて、果樹試験研究推進協議会ニュースレター、vol.9, pp.39-41 (2008) 

38) 村上　明：留学生体験、FOOD Style 21，12(12); 76-77 (2008)

37) 村上　明：メタボがもたらすもの、FOOD Style 21，12(11); 72-73 (2008)

36) 村上　明：ラボディスカッション、FOOD Style 21，12(10); 76-77 (2008)

35) 村上　明：研究の進め方、FOOD Style 21，12(9); 116-117 (2008)

34) 村上　明：査読のお仕事、FOOD Style 21，12(8); 84-85 (2008)

33) 村上　明：英語という難物、FOOD Style 21，12(7); 76-77 (2008)

32) 村上　明：失敗を見つめる、FOOD Style 21，12(6); 81-83 (2008)

31) 村上　明：動物実験　－善悪と要不要－、FOOD Style 21，12(5); 99-101 (2008)

30) 村上　明：卒業論文を仕上げる、FOOD Style 21，12(4); 94-95 (2008)

29) 村上　明：COMTの意図、FOOD Style 21，12(3); 96-98 (2008)

28) 村上　明：国際学会ABC、FOOD Style 21，12(2); 83-85 (2008)

27) 村上　明：研究発表のノウハウ、FOOD Style 21，12(1); 78-80 (2008)

26) 村上　明：スカベンジャー受容体とノビレチン、果樹試験研究推進協議会ニュースレター、vol.5, pp.8-9, (2007)

25) 村上　明：食による発がん予防研究のフロントライン、FOOD Style 21，11(10); 56-58 (2007)

24) 村上　明：基礎実験あれこれ、FOOD Style 21，11(12); 103-105 (2007)

23) 村上　明：健康食品についての雑感、FOOD Style 21，11(11); 92-93 (2007)

22) 村上　明：ICoFFにおける「Cancer Prevention II、FOOD Style 21，11(10); 106-108 (2007)

21) 村上　明：ヒトに潜んでいた植物ホルモン、FOOD Style 21，11(9); 81-83 (2007)

20) 村上　明：食品因子５人衆：後編（その２）、FOOD Style 21，11(8); 85-87 (2007)

19) 村上　明：食品因子５人衆：後編（その１）、FOOD Style 21，11(7); 90-92 (2007)

18) 村上　明：食品因子５人衆：中編．FOOD Style 21、11(6); 84-86 (2007)

17) 村上　明：食品因子５人衆：前編．FOOD Style 21、11(5); 84-86 (2007)

16) 村上　明：誰の責任か？、FOOD Style 21、11(4); 93-95 (2007)

15) 村上　明：2006年を振り返る．FOOD Style 21、11(3); 92-94 (2007)

14) 村上　明：ストレスと鎧（よろい）．FOOD Style 21、11(2); 90-92 (2007)

13) 村上　明：食品因子の標的分子、FOOD Style 21、11(1); 94-96 (2007)

12) 村上　明、大東　肇：ノビレチンの機能性、果樹試験研究推進協議会ニュースレター、vol.2 (2006)

11) 村上　明：教えること、教わること、FOOD Style 21、10(12); 97-99 (2006)

10) 村上　明：クリッカーの心得、FOOD Style 21、10(11); 76-78 (2006)

9) 村上　明：身をもって知った食のパワー、FOOD Style 21、10(10); 110-112 (2006)

8) 村上　明：今が旬！ポリメトキシフラボノイド、FOOD Style 21、10(9); 93-95 (2006)

7) 村上　明：ポリフェノール研究を見つめ直す、FOOD Style 21、10(8); 98-99 (2006)

6) 村上　明：研究の次元、FOOD Style 21、10(7); 81-83 (2006)

5) 村上　明：学会の意義と方向性、FOOD Style 21、10(6); 96-98 (2006) 

4) 村上　明：研究手法を考える、FOOD Style 21、10(5); 82-84 (2006)

3) 村上　明：機能性成分の光と陰、FOOD Style 21、10(4); 96-97 (2006)

2) 村上　明：ポリメトキシフラボノイドの特徴的な活性と代謝特性、日本がん予防研究会ニュースレター, No.30, p.6-7 (2001)

1) 村上　明：カンキツによるがん予防研究の現状、日本がん予防研究会ニュースレター, No.23, p.4-5 (2000)

 

書籍（編集）

 

4) 寺尾純二、村上　明（共編集）、食品学総論　食品の成分と機能、中山書店 (2017)

 

3) 村上　明、森光康次郎　共著：「健康一年生　-食の情報を先生といっしょに考えよう-」、丸善出版社、(2008)

2) 津志田藤二郎、梅垣敬三、井上浩一、村上　明　編著：「機能性食品の安全性ガイドブック」、サイエンスフォーラム (2007) 

1) 村上　明、森光康次郎　編著： 「食と健康　-情報のウラを読む-」 、丸善出版社 (2002)

 

 

書籍（分担）

 

25) 村上　明：天然抗酸化物、吉川敏一監修、内藤裕二、豊國伸哉編集、「酸化ストレスの医学」（改訂第2版、pp.161-168、診断と治療社（2014）

24) 村上　明、宋　美玉：ノビレチン、機能性食品素材の骨と軟骨への応用、pp.242-251、シーエムシー出版（2011）

23) 村上 明：「スパイス」と「ハーブ」、pp.42-43；ターメリックがアレルギーを予防する？、pp.110-112、香辛料研究会編「スパイスなんでも小辞典」、講談社(2011)

22) 村上　明：ハナショウガの機能性、スパイス・ハーブの機能と最新応用技術、pp104-109、シーエムシー出版（2011）

21) 村上　明：フラボノイド -生理機能と疾病予防- 、ビタミン総合事典、pp.457-463、朝倉書店（2010）

20) 村上　明：機能性イソプレノイド（発がん抑制作用）、食品機能性の科学編集委員会編「食品機能性の科学」、pp.59-62、産業技術サービスセンター（2008）

19) 村上　明：天然抗酸化物、吉川敏一監修、内藤裕二、豊國伸哉編集、「酸化ストレスの医学」、pp.147-154、診断と治療社（2008）

18) 村上　明、大東　肇：薬理活性成分、荒井綜一、阿部啓子、吉川敏一、金沢和樹、渡邊　昌　編「機能性食品の事典」、pp. 244-253、朝倉書店 (2007) 

17) 池田泰隆、村上　明、大東　肇：テルペン、荒井綜一、阿部啓子、吉川敏一、金沢和樹、渡邊　昌　編「機能性食品の事典」、朝倉書店 (2007) 

16) 村上　明、大東　肇：多糖類、津志田藤二郎、梅垣敬三、井上浩一、村上　明　編　「機能性食品の安全性ガイドブック」、pp. 351-354、サイエンスフォーラム (2007) 

15) 村上　明、大東　肇：ジアシルグリセロール、津志田藤二郎、梅垣敬三、井上浩一、村上　明　編　「機能性食品の安全性ガイドブック」、pp. 351-354、サイエンスフォーラム (2007) 

14) 村上　明、大東　肇：カテキンなどのポリフェノール、津志田藤二郎、梅垣敬三、井上浩一、村上　明　編　「機能性食品の安全性ガイドブック」、pp. 351-354、サイエンスフォーラム (2007) 

13) 村上　明、大東　肇：動物培養細胞を用いた変異原性評価試験系、津志田藤二郎、梅垣敬三、井上浩一、村上　明　編　「機能性食品の安全性ガイドブック」、PP. 351-354、サイエンスフォーラム (2007) 

12) 村上　明、大東　肇：抗酸化食品成分による発がん予防：現状と展望、「酸化ストレス」、吉川敏一 編、医歯薬出版社、pp.12-15 (2006)

11) 村上　明：RT-PCR法によるmRNA半定量のコツ、「バイオ実験で失敗しない検出と定量のコツ」、森山達哉 編、羊土社、pp.113-119 (2005)

10) 村上　明：第１０章　テルペン、「がん予防食品開発の新展開」、大澤俊彦監修、シーエムシー、pp.191-197 (2005)

9) 村上　明、大東　肇：発がんの分子メカニズムと食品因子、「食品成分のはたらき」、山田耕路　編、朝倉書店、pp.30-41 (2005)

8) 村上　明、大東　肇：発がん予防食品成分の新しい探索源、「食と生活習慣病」、昭和堂、pp.200-208 (2003)

7) 大東　肇、村上　明：癌予防に向けた植物性素材やその有効成分の発掘　-香辛野菜中の特殊成分への期待-、「医学のあゆみ」、医師薬出版、pp.39-44 (2003)

6) 村上　明、大東　肇：食品中抗酸化成分による癌化学予防、医学のあゆみ別冊「酸化ストレス」、医師薬出版、pp.16-19 (2001)

5) 村上　明、大東　肇：高齢者の腫瘍疾患と食品による予防、「長寿食のサイエンス」、サイエンスフォーラム、p.372-381 (2000)

4) 村上　明、大東　肇：野菜・果物成分とがん予防、「がん予防食品」、シーエムシー、pp.281-293 (1999)

3) 村上　明、大東　肇：発がん予防物質の新しい検索対象　-東南アジア産野菜類-　～1'-acetoxychavicol acetateを例として～、「成人病予防食品の開発」、pp.142-148 (1998)

2) 村上　明、小清水弘一、大東　肇：第１０章　グリセロ糖脂質の発がんプロモーション抑制作用、「新しい食品素材と機能」、pp.119-127 (1998)

1) 大東　肇、村上　明、小清水弘一：植物性食素材に含まれる発癌抑制物質、栄養-評価と治療、12、pp. 111-116 (1995)